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Literature summary extracted from

  • Morty, R.E.; Pelle, R.; Vadasz, I.; Uzcanga, G.L.; Seeger, W.; Bubis, J.
    Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts (2005), J. Biol. Chem., 280, 10925-10937.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.83
-
Trypanosoma evansi

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.83 S563A catalytically inactive OpdB variant, no activity with benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin and tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin Trypanosoma evansi

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.83 3,4-dichloroisocoumarin irreversible Trypanosoma evansi
3.4.21.83 4-(2-aminoethyl)benzenesulfonyl fluoride irreversible Trypanosoma evansi
3.4.21.83 agmatine reversible Trypanosoma evansi
3.4.21.83 antipain reversible Trypanosoma evansi
3.4.21.83 benzamidine reversible Trypanosoma evansi
3.4.21.83 leupeptin reversible Trypanosoma evansi
3.4.21.83 phenylmethanesulfonyl fluoride irreversible Trypanosoma evansi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.83 0.0002
-
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0002
-
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0002
-
Val-Lys-Arg-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0003
-
Val-Lys-Arg-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0006
-
Arg-Arg-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0008
-
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.001
-
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.001
-
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0011
-
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0011
-
Arg-Arg-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0011
-
3-(2-furyl)acryloyl-Tyr-Lys-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0012
-
tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0012
-
tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0013
-
tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0013
-
tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0016
-
Gly-Gly-Lys-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0017
-
tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0019
-
3-(2-furyl)acryloyl-Tyr-Lys-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0019
-
tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.002
-
Arg-Arg-2-naphthylamide pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0021
-
tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0021
-
tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0021
-
tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0022
-
Gly-Gly-Lys-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0023
-
benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0024
-
Arg-Arg-2-naphthylamide pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0027
-
Phe-Arg-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0029
-
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.003
-
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.003
-
benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.003
-
Phe-Arg-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.003
-
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.003
-
tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0033
-
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0038
-
Phe-Arg-2-naphthylamide pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.004
-
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0044
-
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0044
-
Ala-Phe-Lys-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0047
-
Gly-Arg-2-naphthylamide pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0048
-
Gly-Arg-2-naphthylamide pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0049
-
Phe-Arg-2-naphthylamide pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.005
-
Ala-Phe-Lys-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0102
-
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.0122
-
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0135
-
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.0143
-
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.04
-
Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.048
-
Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.83 Atrial natriuretic factor + H2O Trypanosoma evansi cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor. The in vitro half-life of atrial natriuretic factor in rat plasma is reduced 300fold in plasma from Trypanosoma evansi infected rodents, which contain high levels of OpdB activity. Oligopeptidase B plays a role in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of atrial natriuretic factor in mammals infected with trypanosoma evansi ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.83 Trypanosoma evansi Q6QDP1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.83
-
Trypanosoma evansi

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.83 additional information Trypanosoma evansi releases oligopeptidase B into the plasma of infected hosts Trypanosoma evansi
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.83 0.017
-
-
Trypanosoma evansi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.83 3-(2-furyl)acryloyl-Tyr-Lys-Arg + H2O
-
Trypanosoma evansi 3-(2-furyl)acryloyl-Tyr-Lys + Arg
-
?
3.4.21.83 Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 Arg-Arg-2-naphthylamide + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 Arg-Arg-Arg-OH + H2O
-
Trypanosoma evansi Arg-Arg + Arg
-
?
3.4.21.83 Atrial natriuretic factor + H2O cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor. The in vitro half-life of atrial natriuretic factor in rat plasma is reduced 300fold in plasma from Trypanosoma evansi infected rodents, which contain high levels of OpdB activity. Oligopeptidase B plays a role in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of atrial natriuretic factor in mammals infected with trypanosoma evansi Trypanosoma evansi ?
-
?
3.4.21.83 Atrial natriuretic factor + H2O cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor Trypanosoma evansi ?
-
?
3.4.21.83 benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 Gly-Arg-2-naphthylamide + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 Gly-Gly-Lys-Arg + H2O
-
Trypanosoma evansi Gly-Gly-Lys-Arg + Arg
-
?
3.4.21.83 Phe-Arg-2-naphthylamide + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 Phe-Arg-Arg + H2O
-
Trypanosoma evansi Phe-Arg + Arg
-
?
3.4.21.83 tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma evansi ?
-
?
3.4.21.83 Val-Lys-Arg-Arg + H2O
-
Trypanosoma evansi Val-Lys-Arg + Arg
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.83 OpdB
-
Trypanosoma evansi

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.83 1
-
Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 2
-
Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 8
-
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 9
-
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 11
-
Gly-Arg-2-naphthylamide pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 12
-
Gly-Arg-2-naphthylamide pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 12
-
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 12
-
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 12
-
3-(2-furyl)acryloyl-Tyr-Lys-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 16
-
Phe-Arg-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 17
-
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 17
-
Phe-Arg-2-naphthylamide pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 18
-
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 18
-
Phe-Arg-2-naphthylamide pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 18
-
3-(2-furyl)acryloyl-Tyr-Lys-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 21
-
Phe-Arg-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 21
-
Arg-Arg-2-naphthylamide pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 22
-
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 23
-
Ala-Phe-Lys-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 26
-
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 29
-
Arg-Arg-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 30
-
Arg-Arg-2-naphthylamide pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 33
-
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C,recombinant enzyme Trypanosoma evansi
3.4.21.83 34
-
Ala-Phe-Lys-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 38
-
Arg-Arg-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 38
-
Val-Lys-Arg-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 40
-
Gly-Gly-Lys-Arg pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 44
-
Val-Lys-Arg-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 48
-
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 54
-
Gly-Gly-Lys-Arg pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 55
-
tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C,recombinant enzyme Trypanosoma evansi
3.4.21.83 57
-
tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 58
-
tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 59
-
benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 59
-
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 64
-
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 64
-
tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 74
-
tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 76
-
tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 77
-
benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 81
-
tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 94
-
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 101
-
tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 102
-
tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 108
-
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 122
-
tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, ecombinant mutant enzyme S563A Trypanosoma evansi
3.4.21.83 132
-
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 154
-
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.83 8.5
-
hydrolysis of benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin Trypanosoma evansi

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.21.83 7 10.5 pH 7.0: about 50% of maximal activity, pH 10.5: about 50% of maximal activity, hydrolysis of benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin Trypanosoma evansi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.83 0.001
-
antipain pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.002
-
antipain pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.021
-
leupeptin pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.029
-
leupeptin pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.188
-
agmatine pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.207
-
agmatine pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi
3.4.21.83 0.218
-
benzamidine pH 8.0, 37°C, native enzyme Trypanosoma evansi
3.4.21.83 0.254
-
benzamidine pH 8.0, 37°C, recombinant enzyme Trypanosoma evansi