EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.83 | - |
Trypanosoma evansi |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.83 | S563A | catalytically inactive OpdB variant, no activity with benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin and tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin | Trypanosoma evansi |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.83 | 3,4-dichloroisocoumarin | irreversible | Trypanosoma evansi | |
3.4.21.83 | 4-(2-aminoethyl)benzenesulfonyl fluoride | irreversible | Trypanosoma evansi | |
3.4.21.83 | agmatine | reversible | Trypanosoma evansi | |
3.4.21.83 | antipain | reversible | Trypanosoma evansi | |
3.4.21.83 | benzamidine | reversible | Trypanosoma evansi | |
3.4.21.83 | leupeptin | reversible | Trypanosoma evansi | |
3.4.21.83 | phenylmethanesulfonyl fluoride | irreversible | Trypanosoma evansi |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.83 | 0.0002 | - |
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0002 | - |
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0002 | - |
Val-Lys-Arg-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0003 | - |
Val-Lys-Arg-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0006 | - |
Arg-Arg-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0008 | - |
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.001 | - |
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.001 | - |
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0011 | - |
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0011 | - |
Arg-Arg-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0011 | - |
3-(2-furyl)acryloyl-Tyr-Lys-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0012 | - |
tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0012 | - |
tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0013 | - |
tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0013 | - |
tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0016 | - |
Gly-Gly-Lys-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0017 | - |
tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0019 | - |
3-(2-furyl)acryloyl-Tyr-Lys-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0019 | - |
tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.002 | - |
Arg-Arg-2-naphthylamide | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0021 | - |
tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0021 | - |
tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0021 | - |
tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0022 | - |
Gly-Gly-Lys-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0023 | - |
benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0024 | - |
Arg-Arg-2-naphthylamide | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0027 | - |
Phe-Arg-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0029 | - |
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.003 | - |
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.003 | - |
benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.003 | - |
Phe-Arg-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.003 | - |
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.003 | - |
tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0033 | - |
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0038 | - |
Phe-Arg-2-naphthylamide | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.004 | - |
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0044 | - |
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0044 | - |
Ala-Phe-Lys-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0047 | - |
Gly-Arg-2-naphthylamide | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0048 | - |
Gly-Arg-2-naphthylamide | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0049 | - |
Phe-Arg-2-naphthylamide | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.005 | - |
Ala-Phe-Lys-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0102 | - |
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0122 | - |
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0135 | - |
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.0143 | - |
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.04 | - |
Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.048 | - |
Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.83 | Atrial natriuretic factor + H2O | Trypanosoma evansi | cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor. The in vitro half-life of atrial natriuretic factor in rat plasma is reduced 300fold in plasma from Trypanosoma evansi infected rodents, which contain high levels of OpdB activity. Oligopeptidase B plays a role in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of atrial natriuretic factor in mammals infected with trypanosoma evansi | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.83 | Trypanosoma evansi | Q6QDP1 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.21.83 | - |
Trypanosoma evansi |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.83 | additional information | Trypanosoma evansi releases oligopeptidase B into the plasma of infected hosts | Trypanosoma evansi | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.4.21.83 | 0.017 | - |
- |
Trypanosoma evansi |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.83 | 3-(2-furyl)acryloyl-Tyr-Lys-Arg + H2O | - |
Trypanosoma evansi | 3-(2-furyl)acryloyl-Tyr-Lys + Arg | - |
? | |
3.4.21.83 | Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | Arg-Arg-2-naphthylamide + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | Arg-Arg-Arg-OH + H2O | - |
Trypanosoma evansi | Arg-Arg + Arg | - |
? | |
3.4.21.83 | Atrial natriuretic factor + H2O | cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor. The in vitro half-life of atrial natriuretic factor in rat plasma is reduced 300fold in plasma from Trypanosoma evansi infected rodents, which contain high levels of OpdB activity. Oligopeptidase B plays a role in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of atrial natriuretic factor in mammals infected with trypanosoma evansi | Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | Atrial natriuretic factor + H2O | cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor | Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | Gly-Arg-2-naphthylamide + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | Gly-Gly-Lys-Arg + H2O | - |
Trypanosoma evansi | Gly-Gly-Lys-Arg + Arg | - |
? | |
3.4.21.83 | Phe-Arg-2-naphthylamide + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | Phe-Arg-Arg + H2O | - |
Trypanosoma evansi | Phe-Arg + Arg | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O | - |
Trypanosoma evansi | ? | - |
? | |
3.4.21.83 | Val-Lys-Arg-Arg + H2O | - |
Trypanosoma evansi | Val-Lys-Arg + Arg | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.83 | OpdB | - |
Trypanosoma evansi |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.83 | 1 | - |
Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 2 | - |
Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 8 | - |
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 9 | - |
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 11 | - |
Gly-Arg-2-naphthylamide | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 12 | - |
Gly-Arg-2-naphthylamide | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 12 | - |
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 12 | - |
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 12 | - |
3-(2-furyl)acryloyl-Tyr-Lys-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 16 | - |
Phe-Arg-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 17 | - |
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 17 | - |
Phe-Arg-2-naphthylamide | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 18 | - |
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 18 | - |
Phe-Arg-2-naphthylamide | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 18 | - |
3-(2-furyl)acryloyl-Tyr-Lys-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 21 | - |
Phe-Arg-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 21 | - |
Arg-Arg-2-naphthylamide | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 22 | - |
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 23 | - |
Ala-Phe-Lys-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 26 | - |
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 29 | - |
Arg-Arg-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 30 | - |
Arg-Arg-2-naphthylamide | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 33 | - |
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C,recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 34 | - |
Ala-Phe-Lys-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 38 | - |
Arg-Arg-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 38 | - |
Val-Lys-Arg-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 40 | - |
Gly-Gly-Lys-Arg | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 44 | - |
Val-Lys-Arg-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 48 | - |
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 54 | - |
Gly-Gly-Lys-Arg | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 55 | - |
tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C,recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 57 | - |
tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 58 | - |
tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 59 | - |
benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 59 | - |
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 64 | - |
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 64 | - |
tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 74 | - |
tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 76 | - |
tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 77 | - |
benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 81 | - |
tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 94 | - |
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 101 | - |
tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 102 | - |
tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 108 | - |
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 122 | - |
tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, ecombinant mutant enzyme S563A | Trypanosoma evansi | |
3.4.21.83 | 132 | - |
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 154 | - |
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.83 | 8.5 | - |
hydrolysis of benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin | Trypanosoma evansi |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.83 | 7 | 10.5 | pH 7.0: about 50% of maximal activity, pH 10.5: about 50% of maximal activity, hydrolysis of benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin | Trypanosoma evansi |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.83 | 0.001 | - |
antipain | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.002 | - |
antipain | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.021 | - |
leupeptin | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.029 | - |
leupeptin | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.188 | - |
agmatine | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.207 | - |
agmatine | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.218 | - |
benzamidine | pH 8.0, 37°C, native enzyme | Trypanosoma evansi | |
3.4.21.83 | 0.254 | - |
benzamidine | pH 8.0, 37°C, recombinant enzyme | Trypanosoma evansi |