Literature summary extracted from

Xu, D.; Wei, Y.; Wu, J.; Dunaway-Mariano, D.; Guo, H.; Cui, Q.; Gao, J.
QM/MM studies of the enzyme-catalyzed dechlorination of 4-chlorobenzoyl-CoA provide insight into reaction energetics (2004), J. Am. Chem. Soc., 126, 13649-13658.

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.8.1.7	G113A	mutation significantly increases the barrier by disrupting the hydrogen bond with the Gly114 backbone	Pseudomonas sp.

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.8.1.7	Pseudomonas sp.	A5JTM5	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.8.1.7	4-chlorobenzoyl-CoA + H2O	reaction rate is limited by the formation of the Meisenheimer comlex, rather than by its decomposition	Pseudomonas sp.	4-hydroxybenzoyl-CoA + chloride	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)