Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rholam, M.; Clamagirand, C.; Cohen, P.
    Magnolysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 1039-1042.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.62 D-Arg12 derivate of pro-oxytocin/neurophysin (1-20)
-
 Bos taurus
3.4.24.62 D-Arg12 derivate of pro-oxytocin/neurophysin (1-20)
-
 Homo sapiens
3.4.24.62 EDTA inhibits at millimolar concentrations Bos taurus
3.4.24.62 EDTA inhibits at millimolar concentrations Homo sapiens
3.4.24.62 EGTA inhibits at millimolar concentrations Bos taurus
3.4.24.62 EGTA inhibits at millimolar concentrations Homo sapiens
3.4.24.62 additional information not inhibited by PMSF, apronitin or pepstatin Bos taurus
3.4.24.62 additional information not inhibited by PMSF, apronitin or pepstatin Homo sapiens
3.4.24.62 p-(chloromercuri)-benzenesulfonic acid partially sensitive to Bos taurus
3.4.24.62 p-(chloromercuri)-benzenesulfonic acid partially sensitive to Homo sapiens
3.4.24.62 PCMB partially sensitive to Bos taurus
3.4.24.62 PCMB partially sensitive to Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.62 55000 65000
-
 Homo sapiens
3.4.24.62 55000 65000
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.62 Bos taurus
-
-
-
3.4.24.62 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.62 affinity chromatography Homo sapiens
3.4.24.62 affinity chromatography Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.62 corpus luteum
-
 Bos taurus
-
3.4.24.62 additional information secretory granule from neurohypophysis hypothalamus Bos taurus
-
3.4.24.62 ovary
-
 Homo sapiens
-
3.4.24.62 ovary
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.62 additional information peptides bearing Nle or D-Arg at subsite P1 or containing Nle or D-Lys at subsite P2 remain uncleaved, substrate bearing the Lys-Arg doublet is hydrolyzed with best efficiency, a minimal length of eight residues is necessary to allow for substrate binding Homo sapiens ?
-
 ?
3.4.24.62 additional information peptides bearing Nle or D-Arg at subsite P1 or containing Nle or D-Lys at subsite P2 remain uncleaved, substrate bearing the Lys-Arg doublet is hydrolyzed with best efficiency, a minimal length of eight residues is necessary to allow for substrate binding Bos taurus ?
-
 ?
3.4.24.62 Pro-oxytocin/neurophysin + H2O primary cleavage at the Arg12-Ala13 bond Homo sapiens ?
-
 ?
3.4.24.62 Pro-oxytocin/neurophysin + H2O primary cleavage at the Arg12-Ala13 bond Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.62 monomer
-
 Homo sapiens
3.4.24.62 monomer
-
 Bos taurus

Synonyms

EC Number Synonyms Comment Organism
3.4.24.62 pro-ocytocin convertase
-
 Homo sapiens
3.4.24.62 pro-ocytocin convertase
-
 Bos taurus
3.4.24.62 pro-ocytocin/neurophysin-converting enzyme
-
 Homo sapiens
3.4.24.62 pro-ocytocin/neurophysin-converting enzyme
-
 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.62 7
-
-
 Homo sapiens
3.4.24.62 7
-
-
 Bos taurus