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Literature summary extracted from

  • Kim, S.; Kurokawa, D.; Watanabe, K.; Makino, S.i.; Shirahata, T.; Watarai, M.
    Brucella abortus nicotinamidase (PncA) contributes to its intracellular replication and infectivity in mice (2004), FEMS Microbiol. Lett., 234, 289-295.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.19 additional information a gene disruption PncA mutant, a nicotinamidase/pyrazinamidase mutant, fails to replicate in HeLa cells and shows lower replication rates compared to the wild-type in macrophages, the mutant does not co-localize with host late endosomes or lysosomes, effects of gene disruption in vivo and in vitro, overview Brucella abortus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.19 nicotinamide + H2O Brucella abortus contributes to the intracellular replication and infectivity of Brucella abortus in mice nicotinate + NH3
-
 ?
3.5.1.19 nicotinamide + H2O Brucella abortus 544 / ATCC 23448 contributes to the intracellular replication and infectivity of Brucella abortus in mice nicotinate + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.19 Brucella abortus
-
 gene pncA, a facultative intracellular pathogen
-
3.5.1.19 Brucella abortus 544 / ATCC 23448
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 gene pncA, a facultative intracellular pathogen
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.19 additional information the pathogen is cultured in human HeLa cells and in murine bone marrow macrophages, co-localizes with host late endosomes or lysosomes Brucella abortus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.19 nicotinamide + H2O
-
 Brucella abortus nicotinate + NH3
-
 ?
3.5.1.19 nicotinamide + H2O contributes to the intracellular replication and infectivity of Brucella abortus in mice Brucella abortus nicotinate + NH3
-
 ?
3.5.1.19 nicotinamide + H2O
-
 Brucella abortus 544 / ATCC 23448 nicotinate + NH3
-
 ?
3.5.1.19 nicotinamide + H2O contributes to the intracellular replication and infectivity of Brucella abortus in mice Brucella abortus 544 / ATCC 23448 nicotinate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.19 PncA
-
 Brucella abortus