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Literature summary extracted from

  • Jarvest, R.L.; Erskine, S.G.; et.al.
    Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase (2005), Bioorg. Med. Chem. Lett., 15, 2305-2309.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.20 1-(3-bromophenyl)-2-[(2-methoxybenzyl)amino]ethanol IC50: 110 nM Staphylococcus aureus
6.1.1.20 1-(3-chlorophenyl)-2-[(2-phenoxybenzyl)amino]ethanol IC50: 31 nM Staphylococcus aureus
6.1.1.20 1-(3-iodophenyl)-2-[(2-phenoxybenzyl)amino]ethanol IC50: 32 nM Staphylococcus aureus
6.1.1.20 1-(3-methoxyphenyl)-2-[(2-phenoxybenzyl)amino]ethanol IC50: 83 nM Staphylococcus aureus
6.1.1.20 1-(4-bromothiophen-2-yl)-2-[(2-methoxybenzyl)amino]ethanol IC50: 50 nM Staphylococcus aureus
6.1.1.20 1-(4-bromothiophen-2-yl)-2-[(2-phenoxybenzyl)amino]ethanol IC50: 120 nM Staphylococcus aureus
6.1.1.20 1-(4-bromothiophen-2-yl)-2-[(2-[[4-(methylsulfonyl)benzyl]oxy]benzyl)amino]ethanol IC50: 26 nM Staphylococcus aureus
6.1.1.20 1-(4-bromothiophen-2-yl)-2-[[2-(2-hydroxyethoxy)benzyl]amino]ethanol IC50: 8 nM Staphylococcus aureus
6.1.1.20 1-(4-bromothiophen-2-yl)-2-[[2-(but-3-en-1-yloxy)benzyl]amino]ethanol IC50: 18 nM Staphylococcus aureus
6.1.1.20 1-(4-bromothiophen-2-yl)-2-[[2-(methoxymethoxy)benzyl]amino]ethanol IC50: 35 nM Staphylococcus aureus
6.1.1.20 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-2-ylmethoxy)benzyl]amino]ethanol IC50: 43 nM Staphylococcus aureus
6.1.1.20 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-3-ylmethoxy)benzyl]amino]ethanol IC50: 18 nM Staphylococcus aureus
6.1.1.20 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-4-ylmethoxy)benzyl]amino]ethanol IC50: 16 nM Staphylococcus aureus
6.1.1.20 1-[3-(hydroxymethyl)phenyl]-2-[(2-phenoxybenzyl)amino]ethanol IC50: 570 nM Staphylococcus aureus
6.1.1.20 2-[(2-methoxybenzyl)amino]-1-(3-methylphenyl)ethanol IC50: 110 nM Staphylococcus aureus
6.1.1.20 2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethoxy)phenyl]ethanol IC50: 190 nM Staphylococcus aureus
6.1.1.20 2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol IC50: 160 nM Staphylococcus aureus
6.1.1.20 2-[(2-methylbenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol IC50: 790 nM Staphylococcus aureus
6.1.1.20 2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]benzoic acid IC50: 2500 nM Staphylococcus aureus
6.1.1.20 2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]phenol IC50: 100 nM Staphylococcus aureus
6.1.1.20 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)acetamide IC50: 110 nM Staphylococcus aureus
6.1.1.20 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-ethylacetamide IC50: 32 nM Staphylococcus aureus
6.1.1.20 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetamide IC50: 42 nM Staphylococcus aureus
6.1.1.20 2-[4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione IC50: 22 nM Staphylococcus aureus
6.1.1.20 2-[[2-(1H-benzimidazol-2-ylmethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol IC50: 26 nM Staphylococcus aureus
6.1.1.20 2-[[2-(2-aminoethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol IC50: 220 nM Staphylococcus aureus
6.1.1.20 2-[[2-(4-aminobutoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol IC50: 22 nM Staphylococcus aureus
6.1.1.20 2-[[2-(benzyloxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol IC50: 10 nM Staphylococcus aureus
6.1.1.20 2-[[2-(benzyloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol IC50: 50 nM Staphylococcus aureus
6.1.1.20 2-[[2-(difluoromethoxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol IC50: 260 nM Staphylococcus aureus
6.1.1.20 2-[[2-(prop-2-en-1-yloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol IC50: 58 nM Staphylococcus aureus
6.1.1.20 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)propanamide IC50: 25 nM Staphylococcus aureus
6.1.1.20 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]propanamide IC50: 36 nM Staphylococcus aureus
6.1.1.20 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]propanoic acid IC50: 58 nM Staphylococcus aureus
6.1.1.20 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)butanamide IC50: 26 nM Staphylococcus aureus
6.1.1.20 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]butanamide IC50: 30 nM Staphylococcus aureus
6.1.1.20 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butanoic acid IC50: 43 nM Staphylococcus aureus
6.1.1.20 N2-[[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetyl]-N-methylglycinamide IC50: 120 nM Staphylococcus aureus
6.1.1.20 [2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetonitrile IC50: 49 nM Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.20 Staphylococcus aureus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
6.1.1.20 FRS
-
Staphylococcus aureus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.1.1.20 0.000008
-
IC50: 8 nM Staphylococcus aureus 1-(4-bromothiophen-2-yl)-2-[[2-(2-hydroxyethoxy)benzyl]amino]ethanol
6.1.1.20 0.00001
-
IC50: 10 nM Staphylococcus aureus 2-[[2-(benzyloxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol
6.1.1.20 0.000016
-
IC50: 16 nM Staphylococcus aureus 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-4-ylmethoxy)benzyl]amino]ethanol
6.1.1.20 0.000018
-
IC50: 18 nM Staphylococcus aureus 1-(4-bromothiophen-2-yl)-2-[[2-(but-3-en-1-yloxy)benzyl]amino]ethanol
6.1.1.20 0.000018
-
IC50: 18 nM Staphylococcus aureus 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-3-ylmethoxy)benzyl]amino]ethanol
6.1.1.20 0.000022
-
IC50: 22 nM Staphylococcus aureus 2-[[2-(4-aminobutoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol
6.1.1.20 0.000022
-
IC50: 22 nM Staphylococcus aureus 2-[4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione
6.1.1.20 0.000025
-
IC50: 25 nM Staphylococcus aureus 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)propanamide
6.1.1.20 0.000026
-
IC50: 26 nM Staphylococcus aureus 1-(4-bromothiophen-2-yl)-2-[(2-[[4-(methylsulfonyl)benzyl]oxy]benzyl)amino]ethanol
6.1.1.20 0.000026
-
IC50: 26 nM Staphylococcus aureus 2-[[2-(1H-benzimidazol-2-ylmethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol
6.1.1.20 0.000026
-
IC50: 26 nM Staphylococcus aureus 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)butanamide
6.1.1.20 0.00003
-
IC50: 30 nM Staphylococcus aureus 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]butanamide
6.1.1.20 0.000031
-
IC50: 31 nM Staphylococcus aureus 1-(3-chlorophenyl)-2-[(2-phenoxybenzyl)amino]ethanol
6.1.1.20 0.000032
-
IC50: 32 nM Staphylococcus aureus 1-(3-iodophenyl)-2-[(2-phenoxybenzyl)amino]ethanol
6.1.1.20 0.000032
-
IC50: 32 nM Staphylococcus aureus 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-ethylacetamide
6.1.1.20 0.000035
-
IC50: 35 nM Staphylococcus aureus 1-(4-bromothiophen-2-yl)-2-[[2-(methoxymethoxy)benzyl]amino]ethanol
6.1.1.20 0.000036
-
IC50: 36 nM Staphylococcus aureus 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]propanamide
6.1.1.20 0.000042
-
IC50: 42 nM Staphylococcus aureus 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetamide
6.1.1.20 0.000043
-
IC50: 43 nM Staphylococcus aureus 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-2-ylmethoxy)benzyl]amino]ethanol
6.1.1.20 0.000043
-
IC50: 43 nM Staphylococcus aureus 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butanoic acid
6.1.1.20 0.000049
-
IC50: 49 nM Staphylococcus aureus [2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetonitrile
6.1.1.20 0.00005
-
IC50: 50 nM Staphylococcus aureus 1-(4-bromothiophen-2-yl)-2-[(2-methoxybenzyl)amino]ethanol
6.1.1.20 0.00005
-
IC50: 50 nM Staphylococcus aureus 2-[[2-(benzyloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol
6.1.1.20 0.000058
-
IC50: 58 nM Staphylococcus aureus 2-[[2-(prop-2-en-1-yloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol
6.1.1.20 0.000058
-
IC50: 58 nM Staphylococcus aureus 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]propanoic acid
6.1.1.20 0.000083
-
IC50: 83 nM Staphylococcus aureus 1-(3-methoxyphenyl)-2-[(2-phenoxybenzyl)amino]ethanol
6.1.1.20 0.0001
-
IC50: 100 nM Staphylococcus aureus 2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]phenol
6.1.1.20 0.00011
-
IC50: 110 nM Staphylococcus aureus 1-(3-bromophenyl)-2-[(2-methoxybenzyl)amino]ethanol
6.1.1.20 0.00011
-
IC50: 110 nM Staphylococcus aureus 2-[(2-methoxybenzyl)amino]-1-(3-methylphenyl)ethanol
6.1.1.20 0.00011
-
IC50: 110 nM Staphylococcus aureus 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)acetamide
6.1.1.20 0.00012
-
IC50: 120 nM Staphylococcus aureus 1-(4-bromothiophen-2-yl)-2-[(2-phenoxybenzyl)amino]ethanol
6.1.1.20 0.00012
-
IC50: 120 nM Staphylococcus aureus N2-[[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetyl]-N-methylglycinamide
6.1.1.20 0.00016
-
IC50: 160 nM Staphylococcus aureus 2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol
6.1.1.20 0.00019
-
IC50: 190 nM Staphylococcus aureus 2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethoxy)phenyl]ethanol
6.1.1.20 0.00022
-
IC50: 220 nM Staphylococcus aureus 2-[[2-(2-aminoethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol
6.1.1.20 0.00026
-
IC50: 260 nM Staphylococcus aureus 2-[[2-(difluoromethoxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol
6.1.1.20 0.00057
-
IC50: 570 nM Staphylococcus aureus 1-[3-(hydroxymethyl)phenyl]-2-[(2-phenoxybenzyl)amino]ethanol
6.1.1.20 0.00079
-
IC50: 790 nM Staphylococcus aureus 2-[(2-methylbenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol
6.1.1.20 0.0025
-
IC50: 2500 nM Staphylococcus aureus 2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]benzoic acid