EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.1.1.20 | 1-(3-bromophenyl)-2-[(2-methoxybenzyl)amino]ethanol | IC50: 110 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(3-chlorophenyl)-2-[(2-phenoxybenzyl)amino]ethanol | IC50: 31 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(3-iodophenyl)-2-[(2-phenoxybenzyl)amino]ethanol | IC50: 32 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(3-methoxyphenyl)-2-[(2-phenoxybenzyl)amino]ethanol | IC50: 83 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(4-bromothiophen-2-yl)-2-[(2-methoxybenzyl)amino]ethanol | IC50: 50 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(4-bromothiophen-2-yl)-2-[(2-phenoxybenzyl)amino]ethanol | IC50: 120 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(4-bromothiophen-2-yl)-2-[(2-[[4-(methylsulfonyl)benzyl]oxy]benzyl)amino]ethanol | IC50: 26 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(4-bromothiophen-2-yl)-2-[[2-(2-hydroxyethoxy)benzyl]amino]ethanol | IC50: 8 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(4-bromothiophen-2-yl)-2-[[2-(but-3-en-1-yloxy)benzyl]amino]ethanol | IC50: 18 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(4-bromothiophen-2-yl)-2-[[2-(methoxymethoxy)benzyl]amino]ethanol | IC50: 35 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-2-ylmethoxy)benzyl]amino]ethanol | IC50: 43 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-3-ylmethoxy)benzyl]amino]ethanol | IC50: 18 nM | Staphylococcus aureus | |
6.1.1.20 | 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-4-ylmethoxy)benzyl]amino]ethanol | IC50: 16 nM | Staphylococcus aureus | |
6.1.1.20 | 1-[3-(hydroxymethyl)phenyl]-2-[(2-phenoxybenzyl)amino]ethanol | IC50: 570 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[(2-methoxybenzyl)amino]-1-(3-methylphenyl)ethanol | IC50: 110 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethoxy)phenyl]ethanol | IC50: 190 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol | IC50: 160 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[(2-methylbenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol | IC50: 790 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]benzoic acid | IC50: 2500 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]phenol | IC50: 100 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)acetamide | IC50: 110 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-ethylacetamide | IC50: 32 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetamide | IC50: 42 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione | IC50: 22 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[[2-(1H-benzimidazol-2-ylmethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol | IC50: 26 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[[2-(2-aminoethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol | IC50: 220 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[[2-(4-aminobutoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol | IC50: 22 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[[2-(benzyloxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol | IC50: 10 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[[2-(benzyloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol | IC50: 50 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[[2-(difluoromethoxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol | IC50: 260 nM | Staphylococcus aureus | |
6.1.1.20 | 2-[[2-(prop-2-en-1-yloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol | IC50: 58 nM | Staphylococcus aureus | |
6.1.1.20 | 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)propanamide | IC50: 25 nM | Staphylococcus aureus | |
6.1.1.20 | 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]propanamide | IC50: 36 nM | Staphylococcus aureus | |
6.1.1.20 | 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]propanoic acid | IC50: 58 nM | Staphylococcus aureus | |
6.1.1.20 | 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)butanamide | IC50: 26 nM | Staphylococcus aureus | |
6.1.1.20 | 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]butanamide | IC50: 30 nM | Staphylococcus aureus | |
6.1.1.20 | 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butanoic acid | IC50: 43 nM | Staphylococcus aureus | |
6.1.1.20 | N2-[[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetyl]-N-methylglycinamide | IC50: 120 nM | Staphylococcus aureus | |
6.1.1.20 | [2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetonitrile | IC50: 49 nM | Staphylococcus aureus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.1.1.20 | Staphylococcus aureus | - |
- |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.1.1.20 | FRS | - |
Staphylococcus aureus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
6.1.1.20 | 0.000008 | - |
IC50: 8 nM | Staphylococcus aureus | 1-(4-bromothiophen-2-yl)-2-[[2-(2-hydroxyethoxy)benzyl]amino]ethanol | |
6.1.1.20 | 0.00001 | - |
IC50: 10 nM | Staphylococcus aureus | 2-[[2-(benzyloxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol | |
6.1.1.20 | 0.000016 | - |
IC50: 16 nM | Staphylococcus aureus | 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-4-ylmethoxy)benzyl]amino]ethanol | |
6.1.1.20 | 0.000018 | - |
IC50: 18 nM | Staphylococcus aureus | 1-(4-bromothiophen-2-yl)-2-[[2-(but-3-en-1-yloxy)benzyl]amino]ethanol | |
6.1.1.20 | 0.000018 | - |
IC50: 18 nM | Staphylococcus aureus | 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-3-ylmethoxy)benzyl]amino]ethanol | |
6.1.1.20 | 0.000022 | - |
IC50: 22 nM | Staphylococcus aureus | 2-[[2-(4-aminobutoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol | |
6.1.1.20 | 0.000022 | - |
IC50: 22 nM | Staphylococcus aureus | 2-[4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione | |
6.1.1.20 | 0.000025 | - |
IC50: 25 nM | Staphylococcus aureus | 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)propanamide | |
6.1.1.20 | 0.000026 | - |
IC50: 26 nM | Staphylococcus aureus | 1-(4-bromothiophen-2-yl)-2-[(2-[[4-(methylsulfonyl)benzyl]oxy]benzyl)amino]ethanol | |
6.1.1.20 | 0.000026 | - |
IC50: 26 nM | Staphylococcus aureus | 2-[[2-(1H-benzimidazol-2-ylmethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol | |
6.1.1.20 | 0.000026 | - |
IC50: 26 nM | Staphylococcus aureus | 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)butanamide | |
6.1.1.20 | 0.00003 | - |
IC50: 30 nM | Staphylococcus aureus | 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]butanamide | |
6.1.1.20 | 0.000031 | - |
IC50: 31 nM | Staphylococcus aureus | 1-(3-chlorophenyl)-2-[(2-phenoxybenzyl)amino]ethanol | |
6.1.1.20 | 0.000032 | - |
IC50: 32 nM | Staphylococcus aureus | 1-(3-iodophenyl)-2-[(2-phenoxybenzyl)amino]ethanol | |
6.1.1.20 | 0.000032 | - |
IC50: 32 nM | Staphylococcus aureus | 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-ethylacetamide | |
6.1.1.20 | 0.000035 | - |
IC50: 35 nM | Staphylococcus aureus | 1-(4-bromothiophen-2-yl)-2-[[2-(methoxymethoxy)benzyl]amino]ethanol | |
6.1.1.20 | 0.000036 | - |
IC50: 36 nM | Staphylococcus aureus | 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-[2-(methylamino)-2-oxoethyl]propanamide | |
6.1.1.20 | 0.000042 | - |
IC50: 42 nM | Staphylococcus aureus | 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetamide | |
6.1.1.20 | 0.000043 | - |
IC50: 43 nM | Staphylococcus aureus | 1-(4-bromothiophen-2-yl)-2-[[2-(pyridin-2-ylmethoxy)benzyl]amino]ethanol | |
6.1.1.20 | 0.000043 | - |
IC50: 43 nM | Staphylococcus aureus | 4-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]butanoic acid | |
6.1.1.20 | 0.000049 | - |
IC50: 49 nM | Staphylococcus aureus | [2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetonitrile | |
6.1.1.20 | 0.00005 | - |
IC50: 50 nM | Staphylococcus aureus | 1-(4-bromothiophen-2-yl)-2-[(2-methoxybenzyl)amino]ethanol | |
6.1.1.20 | 0.00005 | - |
IC50: 50 nM | Staphylococcus aureus | 2-[[2-(benzyloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol | |
6.1.1.20 | 0.000058 | - |
IC50: 58 nM | Staphylococcus aureus | 2-[[2-(prop-2-en-1-yloxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol | |
6.1.1.20 | 0.000058 | - |
IC50: 58 nM | Staphylococcus aureus | 3-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]propanoic acid | |
6.1.1.20 | 0.000083 | - |
IC50: 83 nM | Staphylococcus aureus | 1-(3-methoxyphenyl)-2-[(2-phenoxybenzyl)amino]ethanol | |
6.1.1.20 | 0.0001 | - |
IC50: 100 nM | Staphylococcus aureus | 2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]phenol | |
6.1.1.20 | 0.00011 | - |
IC50: 110 nM | Staphylococcus aureus | 1-(3-bromophenyl)-2-[(2-methoxybenzyl)amino]ethanol | |
6.1.1.20 | 0.00011 | - |
IC50: 110 nM | Staphylococcus aureus | 2-[(2-methoxybenzyl)amino]-1-(3-methylphenyl)ethanol | |
6.1.1.20 | 0.00011 | - |
IC50: 110 nM | Staphylococcus aureus | 2-[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]-N-(3-hydroxypropyl)acetamide | |
6.1.1.20 | 0.00012 | - |
IC50: 120 nM | Staphylococcus aureus | 1-(4-bromothiophen-2-yl)-2-[(2-phenoxybenzyl)amino]ethanol | |
6.1.1.20 | 0.00012 | - |
IC50: 120 nM | Staphylococcus aureus | N2-[[2-([[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl)phenoxy]acetyl]-N-methylglycinamide | |
6.1.1.20 | 0.00016 | - |
IC50: 160 nM | Staphylococcus aureus | 2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol | |
6.1.1.20 | 0.00019 | - |
IC50: 190 nM | Staphylococcus aureus | 2-[(2-methoxybenzyl)amino]-1-[3-(trifluoromethoxy)phenyl]ethanol | |
6.1.1.20 | 0.00022 | - |
IC50: 220 nM | Staphylococcus aureus | 2-[[2-(2-aminoethoxy)benzyl]amino]-1-(4-bromothiophen-2-yl)ethanol | |
6.1.1.20 | 0.00026 | - |
IC50: 260 nM | Staphylococcus aureus | 2-[[2-(difluoromethoxy)benzyl]amino]-1-[3-(trifluoromethyl)phenyl]ethanol | |
6.1.1.20 | 0.00057 | - |
IC50: 570 nM | Staphylococcus aureus | 1-[3-(hydroxymethyl)phenyl]-2-[(2-phenoxybenzyl)amino]ethanol | |
6.1.1.20 | 0.00079 | - |
IC50: 790 nM | Staphylococcus aureus | 2-[(2-methylbenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethanol | |
6.1.1.20 | 0.0025 | - |
IC50: 2500 nM | Staphylococcus aureus | 2-[([2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl]amino)methyl]benzoic acid |