Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Thomas, S.R.; Stocker, R.
    Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway (1999), Redox Rep., 4, 199-220.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.52 alpha-interferon induces IDO expression in monocytes Homo sapiens
1.13.11.52 beta-interferon induces IDO expression in monocytes Homo sapiens
1.13.11.52 gamma-interferon induces IDO expression Mus musculus
1.13.11.52 gamma-interferon induces IDO expression Homo sapiens
1.13.11.52 gamma-interferon induces IDO expression Oryctolagus cuniculus
1.13.11.52 hyperoxia induces IDO expression in the lung Oryctolagus cuniculus
1.13.11.52 lipopolysaccharide induces IDO expression in monocytes Homo sapiens
1.13.11.52 lipopolysaccharide induces IDO expression in the lung Oryctolagus cuniculus
1.13.11.52 paraquat induces IDO expression in the lung Oryctolagus cuniculus

Application

EC Number Application Comment Organism
1.13.11.52 medicine plays a role in the antiparasitic defense in humans, inhibits the growth of tumor cell lines in vitro, inhibits T lymphocyte proliferation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 1-Methyltryptophan treatment of pregnant mice result in rapid T-cell-induces rejection of allogeneic concepti Mus musculus
1.13.11.52 dexamethasone inhibits IDO activity in brain and lung after systemic pokeweed mitogen administration and brains of mice suffering from malaria Mus musculus
1.13.11.52 dexamethasone
-
 Oryctolagus cuniculus
1.13.11.52 H2O2
-
 Homo sapiens
1.13.11.52 H2O2
-
 Mus musculus
1.13.11.52 interleukin-4
-
 Homo sapiens
1.13.11.52 NO
-
 Homo sapiens
1.13.11.52 NO inhibits the transcription of IDO in murine macrophages Mus musculus
1.13.11.52 transforming growth factor-beta inhibits expression in skin and synovial fibroblasts Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-tryptophan + O2 Mus musculus
-
 N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Oryctolagus cuniculus
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens
-
-
-
1.13.11.52 Mus musculus
-
 pregnant
-
1.13.11.52 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 brain
-
 Homo sapiens
-
1.13.11.52 cerebrospinal fluid from humans suffering from inflammatory neurological disorders exhibit increased IDO activity Homo sapiens
-
1.13.11.52 epididymis
-
 Mus musculus
-
1.13.11.52 lung
-
 Mus musculus
-
1.13.11.52 lung
-
 Oryctolagus cuniculus
-
1.13.11.52 lung cancer bearing lung exhibits 20fold increase in IDO activity Homo sapiens
-
1.13.11.52 monocyte induced by alpha-, beta- and gamma-interferon Homo sapiens
-
1.13.11.52 skin fibroblast
-
 Homo sapiens
-
1.13.11.52 small intestine
-
 Mus musculus
-
1.13.11.52 synovial fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-tryptophan + O2
-
 Mus musculus N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Oryctolagus cuniculus N-formyl-L-kynurenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 IDO
-
 Mus musculus
1.13.11.52 IDO
-
 Homo sapiens
1.13.11.52 IDO
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 additional information O2- Mus musculus
1.13.11.52 additional information O2- Homo sapiens
1.13.11.52 additional information O2- Oryctolagus cuniculus