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Literature summary extracted from

  • Tian, J.; Bryk, R.; Itoh, M.; Suematsu, M.; Nathan, C.
    Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase (2005), Proc. Natl. Acad. Sci. USA, 102, 10670-10675.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.71 0.48
-
 2-oxoglutarate 22°C, pH 7.0 Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.71 Mg2+ strictly required, Km-value 0.196 mM Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.71 additional information Mycobacterium tuberculosis enzyme and GabD1 or GabD2 form an alternative pathway from 2-oxoglutarate to succinate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.71 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.71 2-oxoglutarate
-
 Mycobacterium tuberculosis succinate semialdehyde + CO2
-
 ?
4.1.1.71 additional information enzyme and GabD1 or GabD2 form an alternative pathway from 2-oxoglutarate to succinate Mycobacterium tuberculosis ?
-
 ?
4.1.1.71 additional information no substrate: pyruvate Mycobacterium tuberculosis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.71 Kgd
-
 Mycobacterium tuberculosis
4.1.1.71 Rv1248c
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.71 additional information no cofactor: coenzyme A, NAD+, NADP+ Mycobacterium tuberculosis
4.1.1.71 thiamine diphosphate Km-value 0.019 mM Mycobacterium tuberculosis