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Literature summary extracted from

  • Salmen, S.; Hoechstetter, J.; Kaesbauer, C.; Paper, D.H.; Bernhardt, G.; Buschauer, A.
    Sulphated oligosaccharides as inhibitors of hyaluronidases from bovine testis, bee venom and Streptococcus agalactiae (2005), Planta Med., 71, 727-732.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.35 apigenin 52% inhibition at 1 mM and 10 mM Bos taurus
3.2.1.35 beta1,4-galacto-oligosaccharides partially sulfated and non-sulfated forms, especially tri-, tetra-, and pentasaccharides Apis mellifera
3.2.1.35 beta1,4-galacto-oligosaccharides partially sulfated and non-sulfated forms, especially tri-, tetra-, and pentasaccharides, IC50 values Bos taurus
3.2.1.35 kaempferol 36% inhibition at 1 mM Bos taurus
3.2.1.35 additional information inhibition curves, overview Bos taurus
3.2.1.35 partially sulfated neomycin the non-sulfated neomycin is not inhibitory Apis mellifera
3.2.1.35 partially sulfated neomycin the non-sulfated neomycin is not inhibitory Bos taurus
3.2.1.35 partially sulfated planteose the non-sulfated planteose is not inhibitory, IC50 is 0.008 mM Apis mellifera
3.2.1.35 partially sulfated planteose the non-sulfated planteose is not inhibitory, IC50 is 0.005 mM Bos taurus
3.2.1.35 partially sulfated verbascose 2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.040 mM and 0.003 mM Apis mellifera
3.2.1.35 partially sulfated verbascose 2 forms, the non-sulfated verbascose is not inhibitory Bos taurus
3.2.1.35 sulfated 2-hydroxyphenyl monolactobioside IC50 is 0.025 mM Bos taurus
3.2.1.35 sulfated hydroquinone galactoside IC50 is 0.006 mM Apis mellifera
3.2.1.35 sulfated hydroquinone galactoside IC50 is 0.015 mM Bos taurus
4.2.2.1 beta1,4-galacto-oligosaccharides partially sulfated and non-sulfated forms, IC50 values Streptococcus agalactiae
4.2.2.1 additional information inhibition curves, overview Streptococcus agalactiae
4.2.2.1 partially sulfated neomycin the non-sulfated neomycin is not inhibitory Streptococcus agalactiae
4.2.2.1 partially sulfated planteose the non-sulfated planteose is not inhibitory, IC50 is 0.015 mM Streptococcus agalactiae
4.2.2.1 partially sulfated verbascose 2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.030 mM and 0.001 mM Streptococcus agalactiae
4.2.2.1 sulfated 2-hydroxyphenyl monolactobioside IC50 is 0.35 mM Streptococcus agalactiae
4.2.2.1 sulfated hydroquinone galactoside IC50 is 0.080 mM Streptococcus agalactiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.35 extracellular venom Apis mellifera
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.35 hyaluronic acid + H2O Bos taurus
-
 ?
-
 ?
3.2.1.35 hyaluronic acid + H2O Apis mellifera
-
 ?
-
 ?
4.2.2.1 hyaluronic acid Streptococcus agalactiae
-
 ?
-
 ?
4.2.2.1 hyaluronic acid Streptococcus agalactiae 4755
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.35 Apis mellifera
-
-
-
3.2.1.35 Bos taurus
-
-
-
4.2.2.1 Streptococcus agalactiae
-
 gene hylB4755
-
4.2.2.1 Streptococcus agalactiae 4755
-
 gene hylB4755
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.35 commercial preparation from testis Bos taurus
-
3.2.1.35 testis commercial preparation Bos taurus
-
3.2.1.35 venom
-
 Apis mellifera
-
4.2.2.1 commercial preparation purified enzyme Streptococcus agalactiae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.35 hyaluronic acid + H2O
-
 Bos taurus ?
-
 ?
3.2.1.35 hyaluronic acid + H2O
-
 Apis mellifera ?
-
 ?
3.2.1.35 hyaluronic acid + H2O from rooster comb Bos taurus ?
-
 ?
3.2.1.35 hyaluronic acid + H2O from rooster comb Apis mellifera ?
-
 ?
4.2.2.1 hyaluronic acid
-
 Streptococcus agalactiae ?
-
 ?
4.2.2.1 hyaluronic acid from rooster comb Streptococcus agalactiae ?
-
 ?
4.2.2.1 hyaluronic acid
-
 Streptococcus agalactiae 4755 ?
-
 ?
4.2.2.1 hyaluronic acid from rooster comb Streptococcus agalactiae 4755 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.35 BTH
-
 Bos taurus
3.2.1.35 BVH
-
 Apis mellifera
3.2.1.35 hyaluronidase
-
 Bos taurus
3.2.1.35 hyaluronidase
-
 Apis mellifera
4.2.2.1 hylB4755
-
 Streptococcus agalactiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.35 37
-
 assay at Bos taurus
3.2.1.35 37
-
 assay at Apis mellifera
4.2.2.1 37
-
 assay at Streptococcus agalactiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.35 3.6
-
-
 Bos taurus
3.2.1.35 3.6
-
-
 Apis mellifera
4.2.2.1 5
-
-
 Streptococcus agalactiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.35 0.005
-
 the non-sulfated planteose is not inhibitory, IC50 is 0.005 mM Bos taurus partially sulfated planteose
3.2.1.35 0.006
-
 IC50 is 0.006 mM Apis mellifera sulfated hydroquinone galactoside
3.2.1.35 0.008
-
 the non-sulfated planteose is not inhibitory, IC50 is 0.008 mM Apis mellifera partially sulfated planteose
3.2.1.35 0.015
-
 IC50 is 0.015 mM Bos taurus sulfated hydroquinone galactoside
3.2.1.35 0.025
-
 IC50 is 0.025 mM Bos taurus sulfated 2-hydroxyphenyl monolactobioside
3.2.1.35 0.04
-
 2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.040 mM and 0.003 mM Apis mellifera partially sulfated verbascose
4.2.2.1 0.015
-
 the non-sulfated planteose is not inhibitory, IC50 is 0.015 mM Streptococcus agalactiae partially sulfated planteose
4.2.2.1 0.03
-
 2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.030 mM and 0.001 mM Streptococcus agalactiae partially sulfated verbascose
4.2.2.1 0.08
-
 IC50 is 0.080 mM Streptococcus agalactiae sulfated hydroquinone galactoside
4.2.2.1 0.35
-
 IC50 is 0.35 mM Streptococcus agalactiae sulfated 2-hydroxyphenyl monolactobioside