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Literature summary extracted from

  • Funke, I.; Melzig, M.F.
    Effect of different phenolic compounds on alpha-amylase activity: screening by microplate-reader based kinetic assay (2005), Pharmazie, 60, 796-797.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.1 medicine the enzyme is a possible target for treatment of diabetes type 2 Sus scrofa
3.2.1.1 pharmacology the enzyme is a target for development of specific inhibitors for diabetes type 2 therapy Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.1 acarbose IC50 is 0.023 mM Sus scrofa
3.2.1.1 apigenin-7-glucoside IC50 is 0.17 mM Sus scrofa
3.2.1.1 caffeic acid IC50 is 4.8 mM Sus scrofa
3.2.1.1 chlorogenic acid IC50 is 1.4 mM Sus scrofa
3.2.1.1 cynarin IC50 is above 2.0 mM Sus scrofa
3.2.1.1 dihydrocaffeic acid IC50 is above 14.0 mM Sus scrofa
3.2.1.1 ferulic acid IC50 is above 5.0 mM Sus scrofa
3.2.1.1 fisetin IC50 is 0.44 mM Sus scrofa
3.2.1.1 isochlorogenic acid IC50 is 0.56 mM Sus scrofa
3.2.1.1 luteolin IC50 is 0.17 mM Sus scrofa
3.2.1.1 luteolin-7-glucoside IC50 is 0.28 mM Sus scrofa
3.2.1.1 quinic acid IC50 is above 13.0 mM Sus scrofa
3.2.1.1 rosmarinic acid IC50 is 1.4 mM Sus scrofa
3.2.1.1 Sinapic acid IC50 is above 6.7 mM Sus scrofa
3.2.1.1 Tannic acid IC50 is 0.14 mM Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.1 commercial preparation from pancreas Sus scrofa
-
3.2.1.1 pancreas
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.1 additional information
-
 microplate-reader based kinetic assay Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.1 4-nitrophenyl alpha-D-maltopentaoside + H2O
-
 Sus scrofa 4-nitrophenol + alpha-D-maltopentaose
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.1 0.023
-
 IC50 is 0.023 mM Sus scrofa acarbose
3.2.1.1 0.14
-
 IC50 is 0.14 mM Sus scrofa Tannic acid
3.2.1.1 0.17
-
 IC50 is 0.17 mM Sus scrofa luteolin
3.2.1.1 0.17
-
 IC50 is 0.17 mM Sus scrofa apigenin-7-glucoside
3.2.1.1 0.28
-
 IC50 is 0.28 mM Sus scrofa luteolin-7-glucoside
3.2.1.1 0.44
-
 IC50 is 0.44 mM Sus scrofa fisetin
3.2.1.1 0.56
-
 IC50 is 0.56 mM Sus scrofa isochlorogenic acid
3.2.1.1 1.4
-
 IC50 is 1.4 mM Sus scrofa chlorogenic acid
3.2.1.1 1.4
-
 IC50 is 1.4 mM Sus scrofa rosmarinic acid
3.2.1.1 2
-
 IC50 is above 2.0 mM Sus scrofa cynarin
3.2.1.1 4.8
-
 IC50 is 4.8 mM Sus scrofa caffeic acid
3.2.1.1 5
-
 IC50 is above 5.0 mM Sus scrofa ferulic acid
3.2.1.1 6.7
-
 IC50 is above 6.7 mM Sus scrofa Sinapic acid
3.2.1.1 13
-
 IC50 is above 13.0 mM Sus scrofa quinic acid
3.2.1.1 14
-
 IC50 is above 14.0 mM Sus scrofa dihydrocaffeic acid