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Literature summary extracted from

  • Payne, R.J.; Bulloch, E.M.; Abell, A.D.; Abell, C.
    Design and synthesis of aromatic inhibitors of anthranilate synthase (2005), Org. Biomol. Chem., 3, 3629-3635.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.27 (R)-3-(1-carboxy-ethoxy)benzoic acid
-
Serratia marcescens
4.1.3.27 (S)-3-(1-carboxy-ethoxy)benzoic acid
-
Serratia marcescens
4.1.3.27 3-(1-carboxy-ethoxy)-4-hydroxymethyl benzoic acid
-
Serratia marcescens
4.1.3.27 3-(1-carboxy-ethoxy)-4-mercaptomethyl benzoic acid
-
Serratia marcescens
4.1.3.27 3-(1-carboxy-ethoxy)-4-methyl benzoic acid
-
Serratia marcescens
4.1.3.27 3-(1-carboxyethoxy)-4-hydroxybenzoic acid
-
Serratia marcescens
4.1.3.27 3-(1-carboxyethoxy)-4-methoxybenzoic acid
-
Serratia marcescens
4.1.3.27 4-amino-3-(1-carboxyethoxy)benzoic acid
-
Serratia marcescens
4.1.3.27 4-aminomethyl-3-(1-carboxy-ethoxy)benzoate
-
Serratia marcescens
4.1.3.27 4-azidomethyl-3-(1-carboxy-ethoxy)benzoic acid
-
Serratia marcescens

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.27 Serratia marcescens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.27 chorismate + L-Gln
-
Serratia marcescens anthranilate + pyruvate + L-glutamate
-
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Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.3.27 0.0019
-
(S)-3-(1-carboxy-ethoxy)benzoic acid pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.0029
-
3-(1-carboxyethoxy)-4-hydroxybenzoic acid pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.0036
-
(R)-3-(1-carboxy-ethoxy)benzoic acid pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.021
-
3-(1-carboxy-ethoxy)-4-mercaptomethyl benzoic acid pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.021
-
4-azidomethyl-3-(1-carboxy-ethoxy)benzoic acid pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.023
-
4-aminomethyl-3-(1-carboxy-ethoxy)benzoate pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.024
-
3-(1-carboxy-ethoxy)-4-hydroxymethyl benzoic acid pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.025
-
3-(1-carboxyethoxy)-4-methoxybenzoic acid pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.026
-
3-(1-carboxy-ethoxy)-4-methyl benzoic acid pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.043
-
4-amino-3-(1-carboxyethoxy)benzoic acid pH 7.0, 25°C Serratia marcescens