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Literature summary extracted from

  • Le Sann, C.; Gower, M.A.; Abell, A.D.
    Inhibitors of types I and II dehydroquinase (2004), Mini Rev. Med. Chem., 4, 747-756.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.10 (1R,4R,5R)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid
-
Aspergillus nidulans
4.2.1.10 (1R,4R,5R)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid
-
Mycobacterium tuberculosis
4.2.1.10 (1R,4R,5R)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid
-
Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.10 (1R,4R,5R)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid
-
Streptomyces coelicolor
4.2.1.10 (1S,3R,4R)-1,3,4-trihydroxy-5-methylenecyclohexanecarboxylic acid
-
Aspergillus nidulans
4.2.1.10 (1S,3R,4R)-1,3,4-trihydroxy-5-methylenecyclohexanecarboxylic acid
-
Mycobacterium tuberculosis
4.2.1.10 (1S,3R,4R)-1,3,4-trihydroxy-5-methylenecyclohexanecarboxylic acid
-
Streptomyces coelicolor
4.2.1.10 (1S,3R,4R)-1,3,4-trihydroxycyclohexanecarboxylic acid
-
Aspergillus nidulans
4.2.1.10 (1S,3R,4R)-1,3,4-trihydroxycyclohexanecarboxylic acid
-
Mycobacterium tuberculosis
4.2.1.10 (1S,3R,4R)-1,3,4-trihydroxycyclohexanecarboxylic acid
-
Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.10 (1S,3R,4R)-1,3,4-trihydroxycyclohexanecarboxylic acid
-
Streptomyces coelicolor
4.2.1.10 (1S,3R,4R,5E)-1,3,4-trihydroxy-5-(methylimino)cyclohexanecarboxylic acid
-
Aspergillus nidulans
4.2.1.10 (1S,3R,4R,5E)-1,3,4-trihydroxy-5-(methylimino)cyclohexanecarboxylic acid
-
Mycobacterium tuberculosis
4.2.1.10 (1S,3R,4R,5E)-1,3,4-trihydroxy-5-(methylimino)cyclohexanecarboxylic acid
-
Streptomyces coelicolor
4.2.1.10 additional information Ki-values for (1S,3R,4R,5E)-1,3,4-trihydroxy-5-(methylimino)cyclohexanecarboxylic acid and (1S,3R,4R)-1,3,4-trihydroxy-5-methylenecyclohexanecarboxylic acid are above 25 mM Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.10 0.018
-
dehydroquinate
-
Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.10 0.064
-
dehydroquinate
-
Mycobacterium tuberculosis
4.2.1.10 0.15
-
dehydroquinate
-
Aspergillus nidulans
4.2.1.10 0.65
-
dehydroquinate
-
Streptomyces coelicolor

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.10 Aspergillus nidulans
-
-
-
4.2.1.10 Mycobacterium tuberculosis
-
-
-
4.2.1.10 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
4.2.1.10 Streptomyces coelicolor
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.10 3-dehydroquinate
-
Salmonella enterica subsp. enterica serovar Typhimurium 3-dehydroshikimate + H2O
-
?
4.2.1.10 3-dehydroquinate
-
Aspergillus nidulans 3-dehydroshikimate + H2O
-
?
4.2.1.10 3-dehydroquinate
-
Mycobacterium tuberculosis 3-dehydroshikimate + H2O
-
?
4.2.1.10 3-dehydroquinate
-
Streptomyces coelicolor 3-dehydroshikimate + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.10 Type I dehydroquinase
-
Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.10 Type II dehydroquinase
-
Aspergillus nidulans
4.2.1.10 Type II dehydroquinase
-
Mycobacterium tuberculosis
4.2.1.10 Type II dehydroquinase
-
Streptomyces coelicolor

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.10 additional information
-
additional information Ki-values for (1S,3R,4R,5E)-1,3,4-trihydroxy-5-(methylimino)cyclohexanecarboxylic acid and (1S,3R,4R)-1,3,4-trihydroxy-5-methylenecyclohexanecarboxylic acid are above 25 mM Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.10 0.015
-
(1S,3R,4R)-1,3,4-trihydroxy-5-methylenecyclohexanecarboxylic acid
-
Aspergillus nidulans
4.2.1.10 0.02
-
(1S,3R,4R)-1,3,4-trihydroxy-5-methylenecyclohexanecarboxylic acid
-
Mycobacterium tuberculosis
4.2.1.10 0.03
-
(1R,4R,5R)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid
-
Streptomyces coelicolor
4.2.1.10 0.06
-
(1R,4R,5R)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid
-
Aspergillus nidulans
4.2.1.10 0.2
-
(1R,4R,5R)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid
-
Mycobacterium tuberculosis
4.2.1.10 0.5
-
(1S,3R,4R)-1,3,4-trihydroxy-5-methylenecyclohexanecarboxylic acid
-
Streptomyces coelicolor
4.2.1.10 0.6
-
(1S,3R,4R)-1,3,4-trihydroxycyclohexanecarboxylic acid
-
Streptomyces coelicolor
4.2.1.10 0.7
-
(1S,3R,4R,5E)-1,3,4-trihydroxy-5-(methylimino)cyclohexanecarboxylic acid
-
Mycobacterium tuberculosis
4.2.1.10 1.2
-
(1S,3R,4R)-1,3,4-trihydroxycyclohexanecarboxylic acid
-
Mycobacterium tuberculosis
4.2.1.10 1.5
-
(1S,3R,4R)-1,3,4-trihydroxycyclohexanecarboxylic acid
-
Aspergillus nidulans
4.2.1.10 2.2
-
(1S,3R,4R,5E)-1,3,4-trihydroxy-5-(methylimino)cyclohexanecarboxylic acid
-
Aspergillus nidulans
4.2.1.10 2.5
-
(1S,3R,4R,5E)-1,3,4-trihydroxy-5-(methylimino)cyclohexanecarboxylic acid
-
Streptomyces coelicolor
4.2.1.10 3
-
(1R,4R,5R)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid
-
Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.10 4.5
-
(1S,3R,4R)-1,3,4-trihydroxycyclohexanecarboxylic acid
-
Salmonella enterica subsp. enterica serovar Typhimurium