EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Plasmodium falciparum |
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Escherichia coli |
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Pseudomonas aeruginosa |
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Staphylococcus aureus |
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Streptococcus pneumoniae |
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Thermotoga maritima |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.1.88 | expressed as His-tag fusion protein in Escherichia coli | Pseudomonas aeruginosa |
3.5.1.88 | expressed as His-tag fusion protein in Escherichia coli | Staphylococcus aureus |
3.5.1.88 | expressed as His-tag fusion protein in Escherichia coli | Streptococcus pneumoniae |
3.5.1.88 | expressed as His-tag fusion protein in Escherichia coli | Thermotoga maritima |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.5.1.88 | sitting drop vapor diffusion method | Plasmodium falciparum |
3.5.1.88 | sitting drop vapor diffusion method | Escherichia coli |
3.5.1.88 | sitting drop vapor diffusion method | Pseudomonas aeruginosa |
3.5.1.88 | sitting drop vapor diffusion method | Staphylococcus aureus |
3.5.1.88 | sitting drop vapor diffusion method | Streptococcus pneumoniae |
3.5.1.88 | sitting drop vapor diffusion method | Thermotoga maritima |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.88 | Co2+ | can replace Fe2+ without loss of activity, enhances stability | Plasmodium falciparum | |
3.5.1.88 | Co2+ | can replace Fe2+ without loss of activity, enhances stability | Escherichia coli | |
3.5.1.88 | Co2+ | can replace Fe2+ without loss of activity, enhances stability | Staphylococcus aureus | |
3.5.1.88 | Co2+ | can replace Fe2+ without loss of activity, enhances stability | Streptococcus pneumoniae | |
3.5.1.88 | Co2+ | can replace Fe2+ without loss of activity, enhances stability | Thermotoga maritima | |
3.5.1.88 | Fe2+ | required, irreversible oxidation to Fe3+ results in almost complete loss of activity | Plasmodium falciparum | |
3.5.1.88 | Fe2+ | required, irreversible oxidation to Fe3+ results in almost complete loss of activity | Escherichia coli | |
3.5.1.88 | Fe2+ | required, irreversible oxidation to Fe3+ results in almost complete loss of activity | Staphylococcus aureus | |
3.5.1.88 | Fe2+ | required, irreversible oxidation to Fe3+ results in almost complete loss of activity | Streptococcus pneumoniae | |
3.5.1.88 | Fe2+ | required, irreversible oxidation to Fe3+ results in almost complete loss of activity | Thermotoga maritima | |
3.5.1.88 | Ni2+ | can replace Zn2+ | Pseudomonas aeruginosa | |
3.5.1.88 | Ni2+ | can replace Fe2+ without loss of activity, enhances stability | Plasmodium falciparum | |
3.5.1.88 | Ni2+ | can replace Fe2+ without loss of activity, enhances stability | Escherichia coli | |
3.5.1.88 | Ni2+ | can replace Fe2+ without loss of activity, enhances stability | Staphylococcus aureus | |
3.5.1.88 | Ni2+ | can replace Fe2+ without loss of activity, enhances stability | Streptococcus pneumoniae | |
3.5.1.88 | Ni2+ | can replace Fe2+ without loss of activity, enhances stability | Thermotoga maritima | |
3.5.1.88 | Zn2+ | required | Pseudomonas aeruginosa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Plasmodium falciparum | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Escherichia coli | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Pseudomonas aeruginosa | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Staphylococcus aureus | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Streptococcus pneumoniae | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Thermotoga maritima | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Staphylococcus aureus ATCC 2913 | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.88 | Escherichia coli | P0A6K3 | - |
- |
3.5.1.88 | Plasmodium falciparum | - |
- |
- |
3.5.1.88 | Pseudomonas aeruginosa | Q9I7A8 | strain ATCC27853 | - |
3.5.1.88 | Staphylococcus aureus | P68826 | strain ATCC2913 | - |
3.5.1.88 | Staphylococcus aureus ATCC 2913 | P68826 | strain ATCC2913 | - |
3.5.1.88 | Streptococcus pneumoniae | Q9F2F0 | strain ATCC6305 | - |
3.5.1.88 | Thermotoga maritima | P96113 | - |
- |
3.5.1.88 | Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 | P96113 | - |
- |
EC Number | Oxidation Stability | Organism |
---|---|---|
3.5.1.88 | instable towards oxidation due to the oxidation of the metal ligating cysteine residue | Plasmodium falciparum |
3.5.1.88 | instable towards oxidation due to the oxidation of the metal ligating cysteine residue | Escherichia coli |
3.5.1.88 | instable towards oxidation due to the oxidation of the metal ligating cysteine residue | Pseudomonas aeruginosa |
3.5.1.88 | instable towards oxidation due to the oxidation of the metal ligating cysteine residue | Staphylococcus aureus |
3.5.1.88 | instable towards oxidation due to the oxidation of the metal ligating cysteine residue | Streptococcus pneumoniae |
3.5.1.88 | instable towards oxidation due to the oxidation of the metal ligating cysteine residue | Thermotoga maritima |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.1.88 | recombinant enzyme using His-tag | Pseudomonas aeruginosa |
3.5.1.88 | recombinant enzyme using His-tag | Staphylococcus aureus |
3.5.1.88 | recombinant enzyme using His-tag | Streptococcus pneumoniae |
3.5.1.88 | recombinant enzyme using His-tag | Thermotoga maritima |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Plasmodium falciparum | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Escherichia coli | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Pseudomonas aeruginosa | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Staphylococcus aureus | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Streptococcus pneumoniae | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Thermotoga maritima | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Staphylococcus aureus ATCC 2913 | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 | formate + L-methionine-polypeptide | - |
? |