EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Escherichia coli |
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Geobacillus stearothermophilus |
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Pseudomonas aeruginosa |
3.5.1.88 | drug development | potential target or the development of new antibacterial agents | Staphylococcus aureus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.1.88 | expressed in an Escherichia coli deficiency strain | Pseudomonas aeruginosa |
3.5.1.88 | expressed in an Escherichia coli deficiency strain | Staphylococcus aureus |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.5.1.88 | vapor diffusion method | Escherichia coli |
3.5.1.88 | vapor diffusion method | Geobacillus stearothermophilus |
3.5.1.88 | vapor diffusion method | Pseudomonas aeruginosa |
3.5.1.88 | vapor diffusion method | Staphylococcus aureus |
EC Number | General Stability | Organism |
---|---|---|
3.5.1.88 | Ni2+ and Co2+ increase stability compared to the Fe2+ enzyme | Geobacillus stearothermophilus |
3.5.1.88 | Ni2+ and Co2+ increase stability compared to the Fe2+ enzyme | Pseudomonas aeruginosa |
3.5.1.88 | Ni2+ and Co2+ increase stability compared to the Fe2+ enzyme | Staphylococcus aureus |
3.5.1.88 | Ni2+ and Co2+ increases stability compared to the Fe2+ enzyme | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.88 | actinonin | - |
Escherichia coli | |
3.5.1.88 | actinonin | - |
Geobacillus stearothermophilus | |
3.5.1.88 | actinonin | - |
Pseudomonas aeruginosa | |
3.5.1.88 | actinonin | - |
Staphylococcus aureus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.88 | Co2+ | can replace Fe2+ without loss of activity, enhances stability | Escherichia coli | |
3.5.1.88 | Co2+ | can replace Fe2+ without loss of activity, enhances stability | Geobacillus stearothermophilus | |
3.5.1.88 | Co2+ | can replace Fe2+ without loss of activity, enhances stability | Pseudomonas aeruginosa | |
3.5.1.88 | Co2+ | can replace Fe2+ without loss of activity, enhances stability | Staphylococcus aureus | |
3.5.1.88 | Fe2+ | required | Escherichia coli | |
3.5.1.88 | Fe2+ | required | Geobacillus stearothermophilus | |
3.5.1.88 | Fe2+ | required | Pseudomonas aeruginosa | |
3.5.1.88 | Fe2+ | required | Staphylococcus aureus | |
3.5.1.88 | Ni2+ | can replace Fe2+ without loss of activity, enhances stability | Escherichia coli | |
3.5.1.88 | Ni2+ | can replace Fe2+ without loss of activity, enhances stability | Geobacillus stearothermophilus | |
3.5.1.88 | Ni2+ | can replace Fe2+ without loss of activity, enhances stability | Pseudomonas aeruginosa | |
3.5.1.88 | Ni2+ | can replace Fe2+ without loss of activity, enhances stability | Staphylococcus aureus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Escherichia coli | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Geobacillus stearothermophilus | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Pseudomonas aeruginosa | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Staphylococcus aureus | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | Staphylococcus aureus RN4220 | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | formate + L-methionine-polypeptide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.88 | Escherichia coli | P0A6K3 | - |
- |
3.5.1.88 | Geobacillus stearothermophilus | O31410 | - |
- |
3.5.1.88 | Pseudomonas aeruginosa | Q9I7A8 | strain ATCC27853 | - |
3.5.1.88 | Staphylococcus aureus | P68826 | - |
- |
3.5.1.88 | Staphylococcus aureus RN4220 | P68826 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.1.88 | - |
Escherichia coli |
3.5.1.88 | - |
Geobacillus stearothermophilus |
3.5.1.88 | recombinant enzyme | Pseudomonas aeruginosa |
3.5.1.88 | recombinant enzyme | Staphylococcus aureus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Escherichia coli | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Geobacillus stearothermophilus | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Pseudomonas aeruginosa | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Staphylococcus aureus | formate + L-methionine-polypeptide | - |
? | |
3.5.1.88 | N-formyl-L-methionine-polypeptide + H2O | involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides | Staphylococcus aureus RN4220 | formate + L-methionine-polypeptide | - |
? |