EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | p25 | regulatory subunit of Cdk5 | Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.11.22 | drug development | CDKs are important targets for the design of drug with antimitotic and antineurodegenerative effects | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.7.11.22 | CDK6/cyclin V in complex with flavonol inhibitor fisetin, X-ray diffraction structure determination and analysis at 2.9 A resolution, modeling | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | apigenin | a flavonoid inhibitor of CDK6, CDK5, and CDK1 | Homo sapiens | |
2.7.11.22 | chrysin | a flavonoid inhibitor of CDK6, CDK5, and CDK1 | Homo sapiens | |
2.7.11.22 | fisetin | a flavonol inhibitor of CDK6, CDK5, and CDK1, binding structure with CDK6 involving V101, E61, K43, D163, and E99 of CDK6, overview | Homo sapiens | |
2.7.11.22 | flavopiridol | an effective flavonoid inhibitor of CDK6, CDK5, and CDK1 | Homo sapiens | |
2.7.11.22 | kaempferol | a less potent flavonoid inhibitor of CDK6, CDK5, and CDK1 | Homo sapiens | |
2.7.11.22 | luteolin | a flavonoid inhibitor of CDK5 and CDK1 | Homo sapiens | |
2.7.11.22 | additional information | structure-function relationship of flavonoid inhibitors, IC50 values, overview | Homo sapiens | |
2.7.11.22 | quercetin | a less potent flavonoid inhibitor of CDK6, CDK5, and CDK1 | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | Mg2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.22 | additional information | Homo sapiens | the CDKs play a central role in cell cycle control, apoptosis, transcription, and neuronal functions | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.22 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.22 | ATP + histone H1 | - |
Homo sapiens | ADP + phosphorylated histone H1 | - |
? | |
2.7.11.22 | additional information | the CDKs play a central role in cell cycle control, apoptosis, transcription, and neuronal functions | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.22 | Cdk1 | - |
Homo sapiens |
2.7.11.22 | Cdk5 | - |
Homo sapiens |
2.7.11.22 | cdk6 | - |
Homo sapiens |
2.7.11.22 | cyclin-dependent kinase 6 | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.11.22 | 30 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.11.22 | 7 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | ATP | - |
Homo sapiens | |
2.7.11.22 | cyclin B | regulatory subunit of CDK1 | Homo sapiens | |
2.7.11.22 | cyclin V | regulatory subunit of CDK6 | Homo sapiens |