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Literature summary extracted from

  • Lu, H.; Chang, D.J.; Baratte, B.; Meijer, L.; Schulze-Gahmen, U.
    Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin (2005), J. Med. Chem., 48, 737-743.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.22 p25 regulatory subunit of Cdk5 Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.22 drug development CDKs are important targets for the design of drug with antimitotic and antineurodegenerative effects Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.11.22 CDK6/cyclin V in complex with flavonol inhibitor fisetin, X-ray diffraction structure determination and analysis at 2.9 A resolution, modeling Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.22 apigenin a flavonoid inhibitor of CDK6, CDK5, and CDK1 Homo sapiens
2.7.11.22 chrysin a flavonoid inhibitor of CDK6, CDK5, and CDK1 Homo sapiens
2.7.11.22 fisetin a flavonol inhibitor of CDK6, CDK5, and CDK1, binding structure with CDK6 involving V101, E61, K43, D163, and E99 of CDK6, overview Homo sapiens
2.7.11.22 flavopiridol an effective flavonoid inhibitor of CDK6, CDK5, and CDK1 Homo sapiens
2.7.11.22 kaempferol a less potent flavonoid inhibitor of CDK6, CDK5, and CDK1 Homo sapiens
2.7.11.22 luteolin a flavonoid inhibitor of CDK5 and CDK1 Homo sapiens
2.7.11.22 additional information structure-function relationship of flavonoid inhibitors, IC50 values, overview Homo sapiens
2.7.11.22 quercetin a less potent flavonoid inhibitor of CDK6, CDK5, and CDK1 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.22 Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.22 additional information Homo sapiens the CDKs play a central role in cell cycle control, apoptosis, transcription, and neuronal functions ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + histone H1
-
Homo sapiens ADP + phosphorylated histone H1
-
?
2.7.11.22 additional information the CDKs play a central role in cell cycle control, apoptosis, transcription, and neuronal functions Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 Cdk1
-
Homo sapiens
2.7.11.22 Cdk5
-
Homo sapiens
2.7.11.22 cdk6
-
Homo sapiens
2.7.11.22 cyclin-dependent kinase 6
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.22 30
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.22 7
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.22 ATP
-
Homo sapiens
2.7.11.22 cyclin B regulatory subunit of CDK1 Homo sapiens
2.7.11.22 cyclin V regulatory subunit of CDK6 Homo sapiens