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Literature summary extracted from

  • Edmunds, J.W.; Mahadevan, L.C.
    MAP kinases as structural adaptors and enzymatic activators in transcription complexes (2004), J. Cell Sci., 117, 3715-3723.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 12-O-tetradecanoylphorbol-13-acetate activates ERK1 and ERK2 Mammalia
2.7.11.24 MEF2D is crucial for activating phosphorylation of substrates within a transcription complex by BMK1, possibly by anchoring BMK1 to specific genes Mammalia
2.7.11.24 additional information AP1 and NF-kappaB recruit p38 MAPK to activate TBP Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 all-trans retinoic acid receptor ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.24 nucleus
-
 Mammalia 5634
-
2.7.11.24 nucleus
-
 Saccharomyces cerevisiae 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 ATP + AP1 Mammalia substrate of ERK1/2, ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR ADP + phosphorylated AP1
-
 ?
2.7.11.24 ATP + DNA polymerase II Saccharomyces cerevisiae substrate of Hog1p ADP + phosphorylated DNA polymerase II
-
 ?
2.7.11.24 ATP + Hot1p Saccharomyces cerevisiae substrate of Hog1p, phosphorylation of Hot1p is not required for Hot1p-mediated gene expression ADP + phosphorylated Hot1p
-
 ?
2.7.11.24 ATP + TBP Mammalia substrate of p38 MAPK ADP + phosphorylated TBP
-
 ?
2.7.11.24 additional information Mammalia MAPK pathways overview, interaction of MAPKs and transcription factors, overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. ERK1 and ERK2 interact with AP1-complex, which is regulated via the all-trans retinoic acid receptor and TPA, overview ?
-
 ?
2.7.11.24 additional information Saccharomyces cerevisiae MAPK pathways overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. Hog1p, Hot1p, and Sko1p, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Mammalia
-
-
-
2.7.11.24 Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.24 phosphoprotein the MAPKs are phosphorylated and activated by MAPKKs, EC 2.7.11.25, e.g. MKKs or MEKs, overview Mammalia
2.7.11.24 phosphoprotein the MAPKs are phosphorylated and activated by MAPKKs, EC 2.7.11.25, e.g. Ste7p, Pbs2p, or MKK1/2p, overview Saccharomyces cerevisiae

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 macrophage p38 MAPK Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 ATP + AP1 substrate of ERK1/2, ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR Mammalia ADP + phosphorylated AP1
-
 ?
2.7.11.24 ATP + AP1 substrate of ERK1/2 Mammalia ADP + phosphorylated AP1
-
 ?
2.7.11.24 ATP + DNA polymerase II substrate of Hog1p Saccharomyces cerevisiae ADP + phosphorylated DNA polymerase II
-
 ?
2.7.11.24 ATP + Hot1p substrate of Hog1p, phosphorylation of Hot1p is not required for Hot1p-mediated gene expression Saccharomyces cerevisiae ADP + phosphorylated Hot1p
-
 ?
2.7.11.24 ATP + Hot1p substrate of Hog1p Saccharomyces cerevisiae ADP + phosphorylated Hot1p
-
 ?
2.7.11.24 ATP + TBP substrate of p38 MAPK Mammalia ADP + phosphorylated TBP
-
 ?
2.7.11.24 additional information MAPK pathways overview, interaction of MAPKs and transcription factors, overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. ERK1 and ERK2 interact with AP1-complex, which is regulated via the all-trans retinoic acid receptor and TPA, overview Mammalia ?
-
 ?
2.7.11.24 additional information MAPK pathways overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. Hog1p, Hot1p, and Sko1p, overview Saccharomyces cerevisiae ?
-
 ?
2.7.11.24 additional information transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes Mammalia ?
-
 ?
2.7.11.24 additional information transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes Saccharomyces cerevisiae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.24 additional information transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes Mammalia
2.7.11.24 additional information transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 BMK1
-
 Mammalia
2.7.11.24 ERK1
-
 Mammalia
2.7.11.24 ERK2
-
 Mammalia
2.7.11.24 Fus3p
-
 Saccharomyces cerevisiae
2.7.11.24 Hog1p
-
 Saccharomyces cerevisiae
2.7.11.24 JNK1
-
 Mammalia
2.7.11.24 JNK2
-
 Mammalia
2.7.11.24 JNK3
-
 Mammalia
2.7.11.24 Kss1p
-
 Saccharomyces cerevisiae
2.7.11.24 MAP kinase
-
 Mammalia
2.7.11.24 MAP kinase
-
 Saccharomyces cerevisiae
2.7.11.24 MAPK
-
 Mammalia
2.7.11.24 MAPK
-
 Saccharomyces cerevisiae
2.7.11.24 Mpk1p
-
 Saccharomyces cerevisiae
2.7.11.24 p38alpha
-
 Mammalia
2.7.11.24 p38beta
-
 Mammalia
2.7.11.24 p38gamma
-
 Mammalia
2.7.11.24 Smk1p
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.24 ATP
-
 Mammalia
2.7.11.24 ATP
-
 Saccharomyces cerevisiae