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Literature summary extracted from

  • Stadthagen, G.; Kordulakova, J.; Griffin, R.; Constant, P.; Bottova, I.; Barilone, N.; Gicquel, B.; Daffe, M.; Jackson, M.
    p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis (2005), J. Biol. Chem., 280, 40699-40706.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.3.40 production of recombinant enzyme in Escherichia coli and Mycobacterium smegmatis Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.40 4-hydroxybenzoate strong product inhibition Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.3.40 0.00197
-
chorismate pH 7.5, 37°C, recombinant enzyme produced in Mycobacterium smegmatis Mycobacterium tuberculosis
4.1.3.40 0.0396
-
chorismate pH 7.5, 37°C, recombinant enzyme produced in Escherichia coli Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.3.40 Mg2+ required Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.40 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.40 recombinant enzyme produced in Escherichia coli and Mycobacterium smegmatis Mycobacterium tuberculosis

Storage Stability

EC Number Storage Stability Organism
4.1.3.40 -20°C, in presence of 10% glycerol the purified recombinant enzyme is stable for at least 3 weeks Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.40 chorismate
-
Mycobacterium tuberculosis 4-hydroxybenzoate + pyruvate
-
?

Synonyms

EC Number Synonyms Comment Organism
4.1.3.40 Rv2949c enzyme
-
Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.3.40 0.102
-
chorismate pH 7.5, 37°C, recombinant enzyme produced in Mycobacterium smegmatis Mycobacterium tuberculosis
4.1.3.40 0.215
-
chorismate pH 7.5, 37°C, recombinant enzyme produced in Escherichia coli Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.3.40 7.5
-
-
Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.3.40 0.001
-
4-hydroxybenzoate pH 7.5, 37°C Mycobacterium tuberculosis