EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.180 | drug development | the enzyme represents a target for structure-based design of antimycobacterial agents | Mycobacterium tuberculosis |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.3.1.180 | purified FabH, X-ray diffraction structure determination and analysis at 2.1 A resolution | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.180 | myristoyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | the enzyme plays a key role in initiation of the long-chain fatty acid route of meromycolic acid biosynthesis, a different enzyme with specificity for short-chain acyl-CoAs might also be responsible for meromycolic acid biosynthesis, biosynthetic pathway regulation mechanism | 3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.180 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.180 | - |
Mycobacterium tuberculosis |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.3.1.180 | acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | active site structure with a CoA/malonyl-ACP-binding channel leading from the enzyme surface to the buried active site Cys residue, a second channel leads from the active site to the surface with a threonine residue controlling the passage of longer acyl chains | Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.180 | myristoyl-CoA + malonyl-[acyl-carrier protein] | the enzyme plays a key role in initiation of the long-chain fatty acid route of meromycolic acid biosynthesis, a different enzyme with specificity for short-chain acyl-CoAs might also be responsible for meromycolic acid biosynthesis, biosynthetic pathway regulation mechanism | Mycobacterium tuberculosis | 3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | myristoyl-CoA + malonyl-[acyl-carrier protein] | the enzyme prefers long-chain acyl-CoA substrates for the Claisen condensation reaction | Mycobacterium tuberculosis | 3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.180 | beta-ketoacyl-acyl carrier protein synthase III | - |
Mycobacterium tuberculosis |
2.3.1.180 | FabH | - |
Mycobacterium tuberculosis |