EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.3.16 | additional information | PP4 gene disruption by P element mutagenesis leads to a centrosomes-minus-microtubule-homozygous strain which has semi-lethal phenotype with early embryos exhibiting a decreased amount of PPP4c catalytic subunit mRNA and about 25% reduced wild-type PP4 protein | Drosophila melanogaster |
3.1.3.16 | additional information | PP4 knockdown by PPP4c catalytic subunit-RNAi interference leads to a semi-lethal phenotype with abberations in formation of spindles in mitosis and also in sperm meiosis | Caenorhabditis elegans |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.16 | cantharidin | antitumor agent from the chinese blister beetle, strong inhibition of PP4 | Homo sapiens | |
3.1.3.16 | fostriecin | antitumor agent from Streptomyces pulveraceus ssp. fostreus, strong inhibition of PP4 | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.3.16 | centrosome | - |
Drosophila melanogaster | 5813 | - |
3.1.3.16 | centrosome | - |
Homo sapiens | 5813 | - |
3.1.3.16 | centrosome | - |
Saccharomyces cerevisiae | 5813 | - |
3.1.3.16 | centrosome | - |
Caenorhabditis elegans | 5813 | - |
3.1.3.16 | chloroplast | - |
Arabidopsis thaliana | 9507 | - |
3.1.3.16 | cytoplasm | - |
Drosophila melanogaster | 5737 | - |
3.1.3.16 | cytoplasm | - |
Homo sapiens | 5737 | - |
3.1.3.16 | cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
3.1.3.16 | cytoplasm | - |
Caenorhabditis elegans | 5737 | - |
3.1.3.16 | additional information | PP4 is not found at the centrosome in the plants | Arabidopsis thaliana | - |
- |
3.1.3.16 | nucleus | - |
Homo sapiens | 5634 | - |
3.1.3.16 | nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
3.1.3.16 | nucleus | - |
Caenorhabditis elegans | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.16 | additional information | Homo sapiens | the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome and regulation of chromatin activities, it is involved in spliceosomal assembly via interaction with the survival of motor neuron complexes, PP4 regulates several cellular signalling routes, including the NF-kappaB and the target of rapamycin pathways, PP4 plays a role in DNA damage response and decrease histone deacetylase activity, phylogenetic tree and PPP phosphome, overview | ? | - |
? | |
3.1.3.16 | additional information | Caenorhabditis elegans | the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, overview, PP4 depletion results in disrupted centrosome maturation and a decreased number of chiasmata between homologous chromosomes during meiosis in oocytes | ? | - |
? | |
3.1.3.16 | additional information | Drosophila melanogaster | the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, phylogenetic tree and PPP phosphome, overviewe | ? | - |
? | |
3.1.3.16 | additional information | Saccharomyces cerevisiae | the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, PP4 homologues participate in the nutrient sensing pathway, pathway modeling overview, and confers resistance to the anticancer DNA-binding agents cisplatin and oxaliplatin, phylogenetic tree and PPP phosphome, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.16 | Arabidopsis thaliana | - |
- |
- |
3.1.3.16 | Caenorhabditis elegans | - |
- |
- |
3.1.3.16 | Drosophila melanogaster | - |
- |
- |
3.1.3.16 | Homo sapiens | - |
- |
- |
3.1.3.16 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.16 | neuron | - |
Homo sapiens | - |
3.1.3.16 | oocyte | - |
Caenorhabditis elegans | - |
3.1.3.16 | spermatozoon | - |
Caenorhabditis elegans | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.16 | additional information | the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome and regulation of chromatin activities, it is involved in spliceosomal assembly via interaction with the survival of motor neuron complexes, PP4 regulates several cellular signalling routes, including the NF-kappaB and the target of rapamycin pathways, PP4 plays a role in DNA damage response and decrease histone deacetylase activity, phylogenetic tree and PPP phosphome, overview | Homo sapiens | ? | - |
? | |
3.1.3.16 | additional information | the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, overview, PP4 depletion results in disrupted centrosome maturation and a decreased number of chiasmata between homologous chromosomes during meiosis in oocytes | Caenorhabditis elegans | ? | - |
? | |
3.1.3.16 | additional information | the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, phylogenetic tree and PPP phosphome, overviewe | Drosophila melanogaster | ? | - |
? | |
3.1.3.16 | additional information | the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, PP4 homologues participate in the nutrient sensing pathway, pathway modeling overview, and confers resistance to the anticancer DNA-binding agents cisplatin and oxaliplatin, phylogenetic tree and PPP phosphome, overview | Saccharomyces cerevisiae | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.3.16 | More | several catalytic subunit and regulatory subunit forms, properties and interactions, overview | Drosophila melanogaster |
3.1.3.16 | More | several catalytic subunit and regulatory subunit forms, properties and interactions, overview | Homo sapiens |
3.1.3.16 | More | several catalytic subunit and regulatory subunit forms, properties and interactions, overview | Saccharomyces cerevisiae |
3.1.3.16 | More | several catalytic subunit and regulatory subunit forms, properties and interactions, overview | Caenorhabditis elegans |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.16 | Pp4 | - |
Drosophila melanogaster |
3.1.3.16 | Pp4 | - |
Homo sapiens |
3.1.3.16 | Pp4 | - |
Saccharomyces cerevisiae |
3.1.3.16 | Pp4 | - |
Arabidopsis thaliana |
3.1.3.16 | Pp4 | - |
Caenorhabditis elegans |
3.1.3.16 | protein phosphatase 4 | - |
Drosophila melanogaster |
3.1.3.16 | protein phosphatase 4 | - |
Homo sapiens |
3.1.3.16 | protein phosphatase 4 | - |
Saccharomyces cerevisiae |
3.1.3.16 | protein phosphatase 4 | - |
Arabidopsis thaliana |
3.1.3.16 | protein phosphatase 4 | - |
Caenorhabditis elegans |
3.1.3.16 | serine/threonine phosphatase | - |
Drosophila melanogaster |
3.1.3.16 | serine/threonine phosphatase | - |
Homo sapiens |
3.1.3.16 | serine/threonine phosphatase | - |
Saccharomyces cerevisiae |
3.1.3.16 | serine/threonine phosphatase | - |
Arabidopsis thaliana |
3.1.3.16 | serine/threonine phosphatase | - |
Caenorhabditis elegans |