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Literature summary extracted from

  • Cohen, P.T.; Philp, A.; Vazquez-Martin, C.
    Protein phosphatase 4 - from obscurity to vital functions (2005), FEBS Lett., 579, 3278-3286.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.16 additional information PP4 gene disruption by P element mutagenesis leads to a centrosomes-minus-microtubule-homozygous strain which has semi-lethal phenotype with early embryos exhibiting a decreased amount of PPP4c catalytic subunit mRNA and about 25% reduced wild-type PP4 protein Drosophila melanogaster
3.1.3.16 additional information PP4 knockdown by PPP4c catalytic subunit-RNAi interference leads to a semi-lethal phenotype with abberations in formation of spindles in mitosis and also in sperm meiosis Caenorhabditis elegans

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 cantharidin antitumor agent from the chinese blister beetle, strong inhibition of PP4 Homo sapiens
3.1.3.16 fostriecin antitumor agent from Streptomyces pulveraceus ssp. fostreus, strong inhibition of PP4 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.16 centrosome
-
Drosophila melanogaster 5813
-
3.1.3.16 centrosome
-
Homo sapiens 5813
-
3.1.3.16 centrosome
-
Saccharomyces cerevisiae 5813
-
3.1.3.16 centrosome
-
Caenorhabditis elegans 5813
-
3.1.3.16 chloroplast
-
Arabidopsis thaliana 9507
-
3.1.3.16 cytoplasm
-
Drosophila melanogaster 5737
-
3.1.3.16 cytoplasm
-
Homo sapiens 5737
-
3.1.3.16 cytoplasm
-
Saccharomyces cerevisiae 5737
-
3.1.3.16 cytoplasm
-
Caenorhabditis elegans 5737
-
3.1.3.16 additional information PP4 is not found at the centrosome in the plants Arabidopsis thaliana
-
-
3.1.3.16 nucleus
-
Homo sapiens 5634
-
3.1.3.16 nucleus
-
Saccharomyces cerevisiae 5634
-
3.1.3.16 nucleus
-
Caenorhabditis elegans 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.16 additional information Homo sapiens the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome and regulation of chromatin activities, it is involved in spliceosomal assembly via interaction with the survival of motor neuron complexes, PP4 regulates several cellular signalling routes, including the NF-kappaB and the target of rapamycin pathways, PP4 plays a role in DNA damage response and decrease histone deacetylase activity, phylogenetic tree and PPP phosphome, overview ?
-
?
3.1.3.16 additional information Caenorhabditis elegans the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, overview, PP4 depletion results in disrupted centrosome maturation and a decreased number of chiasmata between homologous chromosomes during meiosis in oocytes ?
-
?
3.1.3.16 additional information Drosophila melanogaster the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, phylogenetic tree and PPP phosphome, overviewe ?
-
?
3.1.3.16 additional information Saccharomyces cerevisiae the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, PP4 homologues participate in the nutrient sensing pathway, pathway modeling overview, and confers resistance to the anticancer DNA-binding agents cisplatin and oxaliplatin, phylogenetic tree and PPP phosphome, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Arabidopsis thaliana
-
-
-
3.1.3.16 Caenorhabditis elegans
-
-
-
3.1.3.16 Drosophila melanogaster
-
-
-
3.1.3.16 Homo sapiens
-
-
-
3.1.3.16 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 neuron
-
Homo sapiens
-
3.1.3.16 oocyte
-
Caenorhabditis elegans
-
3.1.3.16 spermatozoon
-
Caenorhabditis elegans
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 additional information the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome and regulation of chromatin activities, it is involved in spliceosomal assembly via interaction with the survival of motor neuron complexes, PP4 regulates several cellular signalling routes, including the NF-kappaB and the target of rapamycin pathways, PP4 plays a role in DNA damage response and decrease histone deacetylase activity, phylogenetic tree and PPP phosphome, overview Homo sapiens ?
-
?
3.1.3.16 additional information the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, overview, PP4 depletion results in disrupted centrosome maturation and a decreased number of chiasmata between homologous chromosomes during meiosis in oocytes Caenorhabditis elegans ?
-
?
3.1.3.16 additional information the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, phylogenetic tree and PPP phosphome, overviewe Drosophila melanogaster ?
-
?
3.1.3.16 additional information the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, PP4 homologues participate in the nutrient sensing pathway, pathway modeling overview, and confers resistance to the anticancer DNA-binding agents cisplatin and oxaliplatin, phylogenetic tree and PPP phosphome, overview Saccharomyces cerevisiae ?
-
?

Subunits

EC Number Subunits Comment Organism
3.1.3.16 More several catalytic subunit and regulatory subunit forms, properties and interactions, overview Drosophila melanogaster
3.1.3.16 More several catalytic subunit and regulatory subunit forms, properties and interactions, overview Homo sapiens
3.1.3.16 More several catalytic subunit and regulatory subunit forms, properties and interactions, overview Saccharomyces cerevisiae
3.1.3.16 More several catalytic subunit and regulatory subunit forms, properties and interactions, overview Caenorhabditis elegans

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 Pp4
-
Drosophila melanogaster
3.1.3.16 Pp4
-
Homo sapiens
3.1.3.16 Pp4
-
Saccharomyces cerevisiae
3.1.3.16 Pp4
-
Arabidopsis thaliana
3.1.3.16 Pp4
-
Caenorhabditis elegans
3.1.3.16 protein phosphatase 4
-
Drosophila melanogaster
3.1.3.16 protein phosphatase 4
-
Homo sapiens
3.1.3.16 protein phosphatase 4
-
Saccharomyces cerevisiae
3.1.3.16 protein phosphatase 4
-
Arabidopsis thaliana
3.1.3.16 protein phosphatase 4
-
Caenorhabditis elegans
3.1.3.16 serine/threonine phosphatase
-
Drosophila melanogaster
3.1.3.16 serine/threonine phosphatase
-
Homo sapiens
3.1.3.16 serine/threonine phosphatase
-
Saccharomyces cerevisiae
3.1.3.16 serine/threonine phosphatase
-
Arabidopsis thaliana
3.1.3.16 serine/threonine phosphatase
-
Caenorhabditis elegans