EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.1 | transient expression of CKII alpha and beta subunits in human U87 astroglioma cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.4.4 | additional information | overexpression of isoforms PLD1 and PLD2, but not their inactive mutants, stimulates Co2+-induced COX-2 expression and prostaglandin E2 production. PLD1 enhances COX-2 expression by Co2+ via reactive oxygen species, p38 MAK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhances Co2+-induced COX-2 expression via reactive oxygen species and p38 MAP kinase, but not PKC-delta, PKA and ERK | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.1 | apigenin | a CKII-specific inhibitor | Homo sapiens | |
2.7.11.1 | emodin | a CKII-specific inhibitor | Homo sapiens | |
3.1.4.4 | 1-butanol | inhibitor of enzyme. Pretreatment with 1-butanol suppresses Co2+-induced COX-2 expression and prostaglandin E2 formation | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.1 | Mn2+ | - |
Homo sapiens | |
3.1.4.4 | Co2+ | stimulation of enzyme activity and synthesis of COX-2 protein in time- and dose-dependent manner. Elevated expression of isoforms PLD1 and PLD2 increases hypoxia-induced COX-2 expression and prostaglandin E2 production. PLD1 enhances COX-2 expression by Co2+ via reactive oxygen species, p38 MAK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhances Co2+-induced COX-2 expression via reactive oxygen species and p38 MAP kinase, but not PKC-delta, PKA and ERK | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.1 | ATP + phospholipase D | Homo sapiens | CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity | ADP + phosphorylated phospholipase D | - |
? | |
3.1.4.4 | additional information | Homo sapiens | protein casein kinase II stimulates basal phospholipase D (PLD1 and PLD2) activity as well as PMA-induced phospholipase D activation in human U87 astroglioma cells | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.1 | Homo sapiens | - |
constitutive enzyme | - |
3.1.4.4 | Homo sapiens | - |
- |
- |
3.1.4.4 | Homo sapiens | O14939 | - |
- |
3.1.4.4 | Homo sapiens | Q13393 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.4 | U-87MG cell | - |
Homo sapiens | - |
3.1.4.4 | U-87MG cell | astroglioma cell | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.1 | ATP + phospholipase D | - |
Homo sapiens | ADP + phosphorylated phospholipase D | - |
? | |
2.7.11.1 | ATP + phospholipase D | CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity | Homo sapiens | ADP + phosphorylated phospholipase D | - |
? | |
3.1.4.4 | additional information | protein casein kinase II stimulates basal phospholipase D (PLD1 and PLD2) activity as well as PMA-induced phospholipase D activation in human U87 astroglioma cells | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.1 | casein kinase-II | - |
Homo sapiens |
2.7.11.1 | protein casein kinase II | - |
Homo sapiens |
3.1.4.4 | PLD1 | - |
Homo sapiens |
3.1.4.4 | PLD2 | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.11.1 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.11.1 | 7.4 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.1 | ATP | - |
Homo sapiens |