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Literature summary extracted from

  • Jensen, J.M.; Forl, M.; Winoto-Morbach, S.; Seite, S.; Schunck, M.; Proksch, E.; Schutze, S.
    Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging (2005), Exp. Dermatol., 14, 609-618.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.23 Detergents required for activity, e.g. NP-40, sodium cholate, Triton X-100, or Tween-20 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Mus musculus A-SMase in the outer epidermis is essential for basal permeability function, A-SMase activity in the lower epidermis is involved in basal permeability barrier homeostasis N-acylsphingosine + choline phosphate
-
 ?
3.5.1.23 additional information Mus musculus the enzyme is involved in degradation of epidermal ceramides, ceramidase activity is not age-dependent ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Mus musculus
-
-
-
3.5.1.23 Mus musculus
-
 8-12-weeks-old hairless SKH-1 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 epidermis unchanged A-SMase activity in the outer epidermis of chronologically aged skin, in the lower epidermis the activity is reduced Mus musculus
-
3.1.4.12 skin
-
 Mus musculus
-
3.5.1.23 skin ceramidase activity is not age-dependent Mus musculus
-
3.5.1.23 stratum corneum
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O A-SMase in the outer epidermis is essential for basal permeability function, A-SMase activity in the lower epidermis is involved in basal permeability barrier homeostasis Mus musculus N-acylsphingosine + choline phosphate
-
 ?
3.5.1.23 additional information the enzyme is involved in degradation of epidermal ceramides, ceramidase activity is not age-dependent Mus musculus ?
-
 ?
3.5.1.23 N-laurylsphingosine + H2O
-
 Mus musculus laureate + sphingosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 A-SMase
-
 Mus musculus
3.5.1.23 acid ceramidase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.23 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.23 4.5
-
 assay at Mus musculus