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Literature summary extracted from

  • Stojan, J.; Brochier, L.; Alies, C.; Colletier, J.P.; Fournier, D.
    Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate (2004), Eur. J. Biochem., 271, 1364-1371.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.7 D375A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 D375G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 E237A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 E237G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 E237Q more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 E69A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 E69I more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 E69K more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 E69L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 E69W more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 E69Y more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330C more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330H more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330I more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330S more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330V more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330W more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F330Y more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F371A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F371G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F371Y more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 F77S more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 G265A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 G368A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 I161K more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 I161T more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 L328A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 L328F more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 M153A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 R70V more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 V182L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 V318A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 V318D more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 W271G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 W321A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 W321L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 W83A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 W83E more than 5% of wild-type activity, shift of inhibition towards higher substrate concentration Drosophila melanogaster
3.1.1.7 W83Y more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y162A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y324A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y370A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y370C more than 5% of wild-type activity, shift of inhibition towards higher substrate concentration Drosophila melanogaster
3.1.1.7 Y370F more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y370L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y370P more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y370S more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y374A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y71A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y71D more than 5% of wild-type activity, shift of inhibition towards higher substrate concentration Drosophila melanogaster
3.1.1.7 Y71K more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y73A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
3.1.1.7 Y73Q more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 4-ketoamyl trimethyl ammonium iodide nonhydrolysable substrate analogue, mechanism of substrate inhibition Drosophila melanogaster
3.1.1.7 Acetylcholine mechanism of substrate inhibition Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Drosophila melanogaster
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