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Literature summary extracted from

  • del Pozo, O.; Pedley, K.F.; Martin, G.B.
    MAPKKKalpha is a positive regulator of cell death associated with both plant immunity and disease (2004), EMBO J., 23, 3072-3082.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.25 DNA and amino acid sequence determination and analysis, sequence comparisons, overview Solanum lycopersicum
2.7.11.25 DNA and amino acid sequence determination and analysis, sequence comparisons, overview, MAPKKKalpha overexpression in leaves using the Agrobacterium tumefaciens transfection system Nicotiana benthamiana

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.25 additional information construction of mutant plants for identification of genes and pathway functioning in hypersensitive response and resistance by MAPKKKalpha silencing, co-expression of tomato resistance R gene Cf9 and the Cladosporium fulvum avirulence gene avr9, a multicomponent transgenic construct, overexpression of the full length Lycopersicon esculentum enzyme or the isolated tomato enzyme kinase domain in leaves leads to pathogen-independent cell death induction, overview Nicotiana benthamiana
2.7.11.25 additional information overexpression of the full length enzyme or the isolated tomato enzyme kinase domain in Nicotiana benthiana leaves leads to pathogen-independent cell death induction, overview Solanum lycopersicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.25 additional information Solanum lycopersicum MAPKKKalpha is responsible for hypersensitive response and resistance to pathogen infection, the enzyme also regulates cell death in susceptible leaves after infection, overview ?
-
 ?
2.7.11.25 additional information Nicotiana benthamiana MAPKKKalpha is responsible for hypersensitive response and resistance to Pseudomonas syringae infection, the enzyme also regulates cell death in susceptible, infected leaves, identification of MAPKKKalpha-induced signal cascades, regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.25 Nicotiana benthamiana Q6RFY4 single copy gene MAPKKKalpha
-
2.7.11.25 Solanum lycopersicum Q6RFY3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.25 leaf
-
 Nicotiana benthamiana
-
2.7.11.25 leaf
-
 Solanum lycopersicum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.25 additional information MAPKKKalpha is responsible for hypersensitive response and resistance to pathogen infection, the enzyme also regulates cell death in susceptible leaves after infection, overview Solanum lycopersicum ?
-
 ?
2.7.11.25 additional information MAPKKKalpha is responsible for hypersensitive response and resistance to Pseudomonas syringae infection, the enzyme also regulates cell death in susceptible, infected leaves, identification of MAPKKKalpha-induced signal cascades, regulation, overview Nicotiana benthamiana ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.25 MAP3Ka
-
 Nicotiana benthamiana
2.7.11.25 MAP3Ka
-
 Solanum lycopersicum
2.7.11.25 MAPKKKalpha
-
 Nicotiana benthamiana
2.7.11.25 MAPKKKalpha
-
 Solanum lycopersicum
2.7.11.25 More MAPKKKalpha belongs to the A2 subgroup of the MEKK enzyme family Nicotiana benthamiana
2.7.11.25 More MAPKKKalpha belongs to the A2 subgroup of the MEKK enzyme family Solanum lycopersicum