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Literature summary extracted from

  • Gallego, M.; Virshup, D.M.
    Protein serine/threonine phosphatases: life, death, and sleeping (2005), Curr. Opin. Cell Biol., 17, 197-202.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.16 additional information knockout of PP2A subunits using dsDNA, and of the two B56 genes leaving A(B56)C and A(PR72)C heterotrimers intact activates caspases and cause apoptosis Drosophila melanogaster
3.1.3.16 additional information PP2A Calpha subunit knockout mice show early embryonic death Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 calyculin A inhibits isozymes PP1, PP4, PP5, and PP2A Homo sapiens
3.1.3.16 calyculin A inhibits PP1, PP4, PP5, and PP2A Mus musculus
3.1.3.16 fostriecin inhibits isozymes PP2A and PP4 Homo sapiens
3.1.3.16 fostriecin inhibits PP2A and PP4 Mus musculus
3.1.3.16 microcystin inhibits isozymes PP1, PP4, PP5, and PP2A Homo sapiens
3.1.3.16 microcystin inhibits PP1, PP4, PP5, and PP2A Mus musculus
3.1.3.16 additional information isozyme PP5 contains an extended N-terminal domain with three tetratricopeptide repeat, TPR, motifs which possesses autoinhibitory function and are important for interaction with other proteins Homo sapiens
3.1.3.16 nodularin inhibits isozymes PP2A, PP5, and PP4 Homo sapiens
3.1.3.16 nodularin inhibits PP2A, PP5, and PP4 Mus musculus
3.1.3.16 okadaic acid inhibits isozymes PP1, PP4, PP5, and PP2A Homo sapiens
3.1.3.16 okadaic acid inhibits PP1, PP4, PP5, and PP2A Mus musculus
3.1.3.16 Protein phosphatase inhibitor-1 inhibits isozyme PP1 Homo sapiens
3.1.3.16 Protein phosphatase inhibitor-1 inhibits PP1 Mus musculus
3.1.3.16 protein phosphatase inhibitor-2 inhibits isozyme PP1 Homo sapiens
3.1.3.16 protein phosphatase inhibitor-2 inhibits PP1 Mus musculus
3.1.3.16 small t antigen of SV40 and polyomavirus inhibits isozyme PP2A Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.16 additional information Lingulodinium polyedra the enzyme is involved in regulation of diverse cellular processes and signaling pathways including circadian rhythm and apoptosis, overview ?
-
 ?
3.1.3.16 additional information Neurospora crassa the enzyme is involved in regulation of diverse cellular processes and signaling pathways including circadian rhythm, moluating the circadian transcription factor FRQ, and apoptosis, overview ?
-
 ?
3.1.3.16 additional information Mus musculus the enzyme is involved in regulation of diverse cellular processes and signaling pathways including embryonic development, cell proliferation, cell death, and cancer, overview, PP5 is involved in stress response negatively regulating ASK-1 dependent apoptosis and promoting tumor growth ?
-
 ?
3.1.3.16 additional information Homo sapiens the enzyme is involved in regulation of diverse cellular processes and signaling pathways including embryonic development, cell proliferation, cell death, and cancer, overview, PP5 is involved in stress response negatively regulating ASK-1 dependent apoptosis and promoting tumor growth, PP2A is regulated by the small t antigen of SV40 and polyomavirus, and is involved in targeting of nuclear transcription factors, e.g. HAND1 and HAND2, overview ?
-
 ?
3.1.3.16 additional information Drosophila melanogaster the enzyme is involved in regulation of diverse cellular processes and signaling pathways including embryonic development, cell proliferation, cell death, circadian rhythm and cancer, overview, knockout of the PP2A regulator alpha4 causes p53-regulated apoptosis correlated with increased phosphorylation of p53 and JNK, PP2A is involved in regulation of PERIOD degradation and de/phosphorylation important in cricadian rhythm, overview ?
-
 ?
3.1.3.16 phosphorylated myosin light chain + H2O Mus musculus isozyme PP1delta regulates smooth muscle relaxation myosin light chain + phosphate
-
 ?
3.1.3.16 phosphorylated myosin light chain + H2O Homo sapiens isozyme PP1delta regulates smooth muscle relaxation myosin light chain + phosphate
-
 ?
3.1.3.16 phosphorylated p53 + H2O Mus musculus
-
 p53 + phosphate
-
 ?
3.1.3.16 phosphorylated p53 + H2O Drosophila melanogaster the B56-containing PP2A acts partly through p53 suppressing apoptosis p53 + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Drosophila melanogaster
-
-
-
3.1.3.16 Homo sapiens
-
 several isozymes, classification, overview
-
3.1.3.16 Lingulodinium polyedra
-
 marine dinoflagellate
-
3.1.3.16 Mus musculus
-
 several isozymes, classification, overview
-
3.1.3.16 Neurospora crassa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.3.16 [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate mechanism of isozyme PP1, the enzyme also performs the reaction of EC 3.1.3.53, myosin-light-chain-phosphatase Homo sapiens
a
3.1.3.16 [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate mechanism of PP1 Mus musculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 smooth muscle isozyme PP1delta Mus musculus
-
3.1.3.16 smooth muscle isozyme PP1delta Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 additional information the enzyme is involved in regulation of diverse cellular processes and signaling pathways including circadian rhythm and apoptosis, overview Lingulodinium polyedra ?
-
 ?
3.1.3.16 additional information the enzyme is involved in regulation of diverse cellular processes and signaling pathways including circadian rhythm, moluating the circadian transcription factor FRQ, and apoptosis, overview Neurospora crassa ?
-
 ?
3.1.3.16 additional information the enzyme is involved in regulation of diverse cellular processes and signaling pathways including embryonic development, cell proliferation, cell death, and cancer, overview, PP5 is involved in stress response negatively regulating ASK-1 dependent apoptosis and promoting tumor growth Mus musculus ?
-
 ?
3.1.3.16 additional information the enzyme is involved in regulation of diverse cellular processes and signaling pathways including embryonic development, cell proliferation, cell death, and cancer, overview, PP5 is involved in stress response negatively regulating ASK-1 dependent apoptosis and promoting tumor growth, PP2A is regulated by the small t antigen of SV40 and polyomavirus, and is involved in targeting of nuclear transcription factors, e.g. HAND1 and HAND2, overview Homo sapiens ?
-
 ?
3.1.3.16 additional information the enzyme is involved in regulation of diverse cellular processes and signaling pathways including embryonic development, cell proliferation, cell death, circadian rhythm and cancer, overview, knockout of the PP2A regulator alpha4 causes p53-regulated apoptosis correlated with increased phosphorylation of p53 and JNK, PP2A is involved in regulation of PERIOD degradation and de/phosphorylation important in cricadian rhythm, overview Drosophila melanogaster ?
-
 ?
3.1.3.16 additional information the different serine/threonine protein phosphatases are associated to a variety of other proteins, e.g. PP1 has about 50 associated proteins, PP5 contains an extended N-terminal domain with three tetratricopeptide repeat, TPR, motifs which possesses autoinhibitory function and are important for interaction with other proteins Homo sapiens ?
-
 ?
3.1.3.16 phosphorylated myosin light chain + H2O isozyme PP1delta regulates smooth muscle relaxation Mus musculus myosin light chain + phosphate
-
 ?
3.1.3.16 phosphorylated myosin light chain + H2O isozyme PP1delta regulates smooth muscle relaxation Homo sapiens myosin light chain + phosphate
-
 ?
3.1.3.16 phosphorylated myosin light chain + H2O isozyme PP1delta, the reaction involves the RVxF-containing myosin phosphatase targeting subunit 1, MYPT1 Mus musculus myosin light chain + phosphate
-
 ?
3.1.3.16 phosphorylated myosin light chain + H2O isozyme PP1delta, the reaction involves the RVxF-containing myosin phosphatase targeting subunit 1, MYPT1 Homo sapiens myosin light chain + phosphate
-
 ?
3.1.3.16 phosphorylated p53 + H2O
-
 Drosophila melanogaster p53 + phosphate
-
 ?
3.1.3.16 phosphorylated p53 + H2O
-
 Mus musculus p53 + phosphate
-
 ?
3.1.3.16 phosphorylated p53 + H2O the B56-containing PP2A acts partly through p53 suppressing apoptosis Drosophila melanogaster p53 + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.16 heterodimer
-
 Neurospora crassa
3.1.3.16 heterodimer
-
 Lingulodinium polyedra
3.1.3.16 More the enzymes are monomers or heterodimers, the different serine/threonine protein phosphatases are formed by different catalytic subunits forming the different isozymes Drosophila melanogaster
3.1.3.16 More the enzymes are monomers or heterodimers, the different serine/threonine protein phosphatases are formed by different catalytic subunits forming the different isozymes Mus musculus
3.1.3.16 More the enzymes are monomers or heterodimers, the different serine/threonine protein phosphatases are formed by only some different catalytic subunits forming the different isozymes in humans, isozyme PP5 contains an extended N-terminal domain with three tetratricopeptide repeat, TPR, motifs which possesses autoinhibitory function and are important for interaction with other proteins Homo sapiens
3.1.3.16 trimer the isozyme PP2A is composed of subunits A, C, and B56gamma Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 More the enzyme belongs to the phosphoprotein phosphatase family Drosophila melanogaster
3.1.3.16 More the enzyme belongs to the phosphoprotein phosphatase family Mus musculus
3.1.3.16 More the enzyme belongs to the phosphoprotein phosphatase family Neurospora crassa
3.1.3.16 More the enzyme belongs to the phosphoprotein phosphatase family Lingulodinium polyedra
3.1.3.16 More the enzyme belongs to the phosphoprotein phosphatase family, cf. EC 3.1.3.53, myosin-light-chain-phosphatase Homo sapiens
3.1.3.16 PP
-
 Drosophila melanogaster
3.1.3.16 PP
-
 Mus musculus
3.1.3.16 PP1
-
 Neurospora crassa
3.1.3.16 PP1
-
 Lingulodinium polyedra
3.1.3.16 PP2A
-
 Neurospora crassa
3.1.3.16 PP2A
-
 Lingulodinium polyedra
3.1.3.16 protein serine/threonine phosphatase
-
 Drosophila melanogaster
3.1.3.16 protein serine/threonine phosphatase
-
 Mus musculus
3.1.3.16 protein serine/threonine phosphatase
-
 Homo sapiens
3.1.3.16 protein serine/threonine phosphatase
-
 Neurospora crassa
3.1.3.16 protein serine/threonine phosphatase
-
 Lingulodinium polyedra
3.1.3.16 PSTP
-
 Drosophila melanogaster
3.1.3.16 PSTP
-
 Mus musculus
3.1.3.16 PSTP
-
 Homo sapiens
3.1.3.16 PSTP
-
 Neurospora crassa
3.1.3.16 PSTP
-
 Lingulodinium polyedra