Literature summary extracted from

Contreras, F.X.; Sot, J.; Ruiz-Arguello, M.B.; Alonso, A.; Goni, F.M.
Cholesterol modulation of sphingomyelinase activity at physiological temperatures (2004), Chem. Phys. Lipids, 130, 127-134.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.4.12	cholesterol	sphingomyelinase activity is higher in the cholesterol-induced liquid-ordered phase than in the gel phase	Bacillus cereus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.4.12	sphingomyelin + H2O	Bacillus cereus	cholesterol activation of sphingomyelinase and the strong affinity of cholesterol for sphingomyelin allows the rapid, localized and self-contained production of the metabolic signal ceramide in specific microdomains	N-acylsphingosine + choline phosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.12	Bacillus cereus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.12	sphingomyelin + H2O	-	Bacillus cereus	N-acylsphingosine + choline phosphate	-	?
3.1.4.12	sphingomyelin + H2O	cholesterol activation of sphingomyelinase and the strong affinity of cholesterol for sphingomyelin allows the rapid, localized and self-contained production of the metabolic signal ceramide in specific microdomains	Bacillus cereus	N-acylsphingosine + choline phosphate	-	?

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Release 2023.1 (January 2023)