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Literature summary extracted from
- Remarkable enhancement of the hydrolyses of phosphoesters by dinuclear centers: Streptomyces aminopeptidase as a 'natural model system' (2000), Chem. Commun. (Camb.), 1, 2501-2502.
No PubMed abstract available
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.11.24 | 2.4 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Cd2+-enzyme | Streptomyces sp. |  |
| 3.4.11.24 | 3 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Ni2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 4.5 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Zn2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 4.9 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Mn2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 7.9 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Co2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 9.5 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Co2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 9.7 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Cd2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 10.6 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Ni2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 12 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Mn2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 14.9 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Zn2+-enzyme | Streptomyces sp. | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.24 | Cd2+ | dinuclear metal-enzyme derivative, structure | Streptomyces sp. | |
| 3.4.11.24 | Co2+ | dinuclear metal-enzyme derivative, structure | Streptomyces sp. | |
| 3.4.11.24 | Mn2+ | dinuclear metal-enzyme derivative, structure | Streptomyces sp. | |
| 3.4.11.24 | additional information | the enzyme possesses dinuclear metal cluster | Streptomyces sp. | |
| 3.4.11.24 | Ni2+ | dinuclear metal-enzyme derivative, structure | Streptomyces sp. | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.24 | Streptomyces sp. | - |
- |
- |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.24 | 0.0016 | - |
Ni2+-enzyme, substrate 4-nitrophenyl phenylphosphonate | Streptomyces sp. |
| 3.4.11.24 | 0.0016 | - |
Ni2+-enzyme, substrate bis(4-nitrophenyl) phosphate | Streptomyces sp. |
| 3.4.11.24 | 0.0017 | - |
Zn2+-enzyme, substrate 4-nitrophenyl phenylphosphonate | Streptomyces sp. |
| 3.4.11.24 | 0.0033 | - |
Mn2+-enzyme, substrate 4-nitrophenyl phenylphosphonate | Streptomyces sp. |
| 3.4.11.24 | 0.0048 | - |
Co2+-enzyme, substrate 4-nitrophenyl phenylphosphonate | Streptomyces sp. |
| 3.4.11.24 | 0.0078 | - |
Cd2+-enzyme, substrate bis(4-nitrophenyl) phosphate | Streptomyces sp. |
| 3.4.11.24 | 0.0097 | - |
Cd2+-enzyme, substrate 4-nitrophenyl phenylphosphonate | Streptomyces sp. |
| 3.4.11.24 | 0.031 | - |
Mn2+-enzyme, substrate bis(4-nitrophenyl) phosphate | Streptomyces sp. |
| 3.4.11.24 | 0.136 | - |
Co2+-enzyme, substrate bis(4-nitrophenyl) phosphate | Streptomyces sp. |
| 3.4.11.24 | 0.158 | - |
Zn2+-enzyme, substrate bis(4-nitrophenyl) phosphate | Streptomyces sp. |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.24 | 4-nitrophenyl phenylphosphonate + H2O | - |
Streptomyces sp. | 4-nitrophenol + phenylphosphonate | - |
? | |
| 3.4.11.24 | bis(4-nitrophenyl) phosphate + H2O | - |
Streptomyces sp. | 4-nitrophenol + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.11.24 | Streptomyces aminopeptidase | - |
Streptomyces sp. |
| 3.4.11.24 | Streptomyces dinuclear aminopeptidase | - |
Streptomyces sp. |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.24 | 30 | - |
assay at, substrate bis(4-nitrophenyl) phosphate | Streptomyces sp. |
| 3.4.11.24 | 50 | - |
assay at, substrate 4-nitrophenyl phenylphosphonate | Streptomyces sp. |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.11.24 | 0.0033 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Ni2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 0.01 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Ni2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 0.01 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Mn2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 0.014 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Zn2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 0.017 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Cd2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 0.022 | - |
4-nitrophenyl phenylphosphonate | pH 8.0, 50°C, Co2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 0.043 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Cd2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 0.21 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Mn2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 0.45 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Zn2+-enzyme | Streptomyces sp. | |
| 3.4.11.24 | 0.74 | - |
bis(4-nitrophenyl) phosphate | pH 8.0, 30°C, Co2+-enzyme | Streptomyces sp. | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.24 | 8 | - |
assay at | Streptomyces sp. |
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