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Literature summary extracted from

  • Sanon, A.; Tournaire-Arellano, C.; El Hage, S.Y.; Bories, C.; Caujolle, R.; Loiseau, P.M.
    N-acetyl-beta-D-hexosaminidase from Trichomonas vaginalis: substrate specificity and activity of inhibitors (2005), Biomed. Pharmacother., 59, 245-248.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.52 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[3-(1-adamantyl)ureido]-beta-D-glucopyranose 0.1 mM Trichomonas vaginalis
3.2.1.52 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[3-(2-allyl)thioureido]-beta-D-glucopyranose 0.1 mM Trichomonas vaginalis
3.2.1.52 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[3-(2-cyclohexyl)ureido]-beta-D-glucopyranose 0.1 mM Trichomonas vaginalis
3.2.1.52 1,3-bis[3-(1-deoxy-D-glucit-1-yl)ureido]-4-methylbenzene 0.1 mM Trichomonas vaginalis
3.2.1.52 1,6-bis[3-(1,3,4,6-tetra-O-acetyl-2-deoxy-beta-D-glucopyranos-2-yl)ureido]hexane 0.1 mM Trichomonas vaginalis
3.2.1.52 1,6-bis{1-[3-(1-deoxy-D-glucit-1-yl)]ureido}hexane 0.1 mM Trichomonas vaginalis
3.2.1.52 1,8-bis[3-(1,3,4,6-tetra-O-acetyl-2-deoxy-beta-D-glucopyranos-2-yl)ureido]octane 0.1 mM Trichomonas vaginalis
3.2.1.52 1,9-bis-[3-(2-hydroxyethoxy)ethylthioureido]-nonane 0.1 mM Trichomonas vaginalis
3.2.1.52 1,9-bis{1-[3-(1-deoxy-D-glucit-1-yl)]thioureido}nonane 0.1 mM Trichomonas vaginalis
3.2.1.52 1-deoxy-1-(3-adamantylthioureido)-D-glucitol 0.1 mM Trichomonas vaginalis
3.2.1.52 1-deoxy-1-(3-cyclohexylureido)-D-glucitol 0.1 mM Trichomonas vaginalis
3.2.1.52 1-deoxy-1-[3-(1-adamantyl)ureido]-D-glucitol 0.1 mM Trichomonas vaginalis
3.2.1.52 AgNO3 1 mM final concentration Trichomonas vaginalis
3.2.1.52 CuSO4 1-10 mM final concentration Trichomonas vaginalis
3.2.1.52 HgCl2 1 mM final concentration Trichomonas vaginalis
3.2.1.52 NaCl 10 mM final concentration Trichomonas vaginalis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.52 0.006
-
 4-methylumbelliferyl-beta-D-glucosaminide
-
 Trichomonas vaginalis
3.2.1.52 0.653
-
 p-nitrophenyl-N-acetyl-beta-D-glucosaminide
-
 Trichomonas vaginalis

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.52 Trichomonas vaginalis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.52
-
 Trichomonas vaginalis

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.52 1.227
-
 4-methylumbelliferyl-beta-D-glucosaminide Trichomonas vaginalis
3.2.1.52 2.412
-
 p-nitrophenyl-N-acetyl-beta-D-glucosaminide Trichomonas vaginalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.52 4-methylumbelliferyl-beta-D-glucosaminide + H2O
-
 Trichomonas vaginalis 4-methylumbelliferol + beta-D-glucosamine
-
 ?
3.2.1.52 p-nitrophenyl-N-acetyl-beta-D-glucosaminide + H2O
-
 Trichomonas vaginalis p-nitrophenol + N-acetyl-beta-D-glucosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.52 N-acetyl-beta-D-hexosaminidase
-
 Trichomonas vaginalis
3.2.1.52 NAHase
-
 Trichomonas vaginalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.52 4.5
-
 on 4-methylumbelliferyl-beta-D-glucosaminide substrate Trichomonas vaginalis
3.2.1.52 7
-
 on p-nitrophenyl-N-acetyl-beta-D-glucosaminide substrate Trichomonas vaginalis