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Literature summary extracted from

  • Jin, W.; Arakawa, Y.; Yasuzawa, H.; Taki, T.; Hashiguchi, R.; Mitsutani, K.; Shoga, A.; Yamaguchi, Y.; Kurosaki, H.; Shibata, N.; Ohta, M.; Goto, M.
    Comparative study of the inhibition of metallo-beta-lactamases (IMP-1 and VIM-2) by thiol compounds that contain a hydrophobic group (2004), Biol. Pharm. Bull., 27, 851-856.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.2.6 expression in Escherichia coli Pseudomonas aeruginosa
3.5.2.6 expression in Escherichia coli Serratia marcescens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 2-(mercaptomethyl)-4-phenylbutanoic acid IC50: 0.0026 mM Pseudomonas aeruginosa
3.5.2.6 2-(mercaptomethyl)-4-phenylbutanoic acid IC50: 0.0074 mM Serratia marcescens
3.5.2.6 2-(mercaptomethyl)-5-phenylpentanoic acid IC50: 0.0013 mM Pseudomonas aeruginosa
3.5.2.6 2-(mercaptomethyl)-5-phenylpentanoic acid IC50: 0.0097 mM Serratia marcescens
3.5.2.6 2-(mercaptomethyl)-6-phenylhexanoic acid IC50: 0.0011 mM Pseudomonas aeruginosa
3.5.2.6 2-(mercaptomethyl)-6-phenylhexanoic acid IC50: 0.0012 mM Serratia marcescens
3.5.2.6 2-benzyl-3-mercaptopropanoic acid IC50: 0.0143 mM Pseudomonas aeruginosa
3.5.2.6 2-benzyl-3-mercaptopropanoic acid IC50: 0.0164 mM Serratia marcescens
3.5.2.6 N-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-3-mercapto-propionamide IC50: 0.0063 mM Pseudomonas aeruginosa
3.5.2.6 N-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-3-mercapto-propionamide IC50: 0.0142 mM Serratia marcescens
3.5.2.6 N-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-mercapto-propionamide IC50: 0.0065 mM Pseudomonas aeruginosa
3.5.2.6 N-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-mercapto-propionamide IC50: 0.0066 mM Serratia marcescens
3.5.2.6 N-[4-(7-chloro-quinolin-4-ylamino)-butyl]-3-mercapto-propionamide IC50: 0.0024 mM Pseudomonas aeruginosa
3.5.2.6 N-[4-(7-chloro-quinolin-4-ylamino)-butyl]-3-mercapto-propionamide IC50: 0.0025 mM Serratia marcescens
3.5.2.6 N-[5-(7-chloro-quinolin-4-ylamino)-pentyl]-3-mercapto-propionamide IC50: 0.0076 mM Pseudomonas aeruginosa
3.5.2.6 N-[5-(7-chloro-quinolin-4-ylamino)-pentyl]-3-mercapto-propionamide IC50: 0.0067 mM Serratia marcescens
3.5.2.6 N-[6-(7-cloro-quinolin-4-ylamino)-hexyl]-3-mercapto-propionamide IC50: 0.0049 mM Pseudomonas aeruginosa
3.5.2.6 N-[6-(7-cloro-quinolin-4-ylamino)-hexyl]-3-mercapto-propionamide IC50: 0.0034 mM Serratia marcescens

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Pseudomonas aeruginosa
-
-
-
3.5.2.6 Serratia marcescens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
 Pseudomonas aeruginosa
3.5.2.6
-
 Serratia marcescens

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 metallo-beta-lactamase IMP-1
-
 Serratia marcescens
3.5.2.6 metallo-beta-lactamase VIM-2
-
 Pseudomonas aeruginosa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.2.6 0.0011
-
 IC50: 0.0011 mM Pseudomonas aeruginosa 2-(mercaptomethyl)-6-phenylhexanoic acid
3.5.2.6 0.0012
-
 IC50: 0.0012 mM Serratia marcescens 2-(mercaptomethyl)-6-phenylhexanoic acid
3.5.2.6 0.0013
-
 IC50: 0.0013 mM Pseudomonas aeruginosa 2-(mercaptomethyl)-5-phenylpentanoic acid
3.5.2.6 0.0024
-
 IC50: 0.0024 mM Pseudomonas aeruginosa N-[4-(7-chloro-quinolin-4-ylamino)-butyl]-3-mercapto-propionamide
3.5.2.6 0.0025
-
 IC50: 0.0025 mM Serratia marcescens N-[4-(7-chloro-quinolin-4-ylamino)-butyl]-3-mercapto-propionamide
3.5.2.6 0.0026
-
 IC50: 0.0026 mM Pseudomonas aeruginosa 2-(mercaptomethyl)-4-phenylbutanoic acid
3.5.2.6 0.0034
-
 IC50: 0.0034 mM Serratia marcescens N-[6-(7-cloro-quinolin-4-ylamino)-hexyl]-3-mercapto-propionamide
3.5.2.6 0.0049
-
 IC50: 0.0049 mM Pseudomonas aeruginosa N-[6-(7-cloro-quinolin-4-ylamino)-hexyl]-3-mercapto-propionamide
3.5.2.6 0.0063
-
 IC50: 0.0063 mM Pseudomonas aeruginosa N-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-3-mercapto-propionamide
3.5.2.6 0.0065
-
 IC50: 0.0065 mM Pseudomonas aeruginosa N-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-mercapto-propionamide
3.5.2.6 0.0066
-
 IC50: 0.0066 mM Serratia marcescens N-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-mercapto-propionamide
3.5.2.6 0.0067
-
 IC50: 0.0067 mM Serratia marcescens N-[5-(7-chloro-quinolin-4-ylamino)-pentyl]-3-mercapto-propionamide
3.5.2.6 0.0074
-
 IC50: 0.0074 mM Serratia marcescens 2-(mercaptomethyl)-4-phenylbutanoic acid
3.5.2.6 0.0076
-
 IC50: 0.0076 mM Pseudomonas aeruginosa N-[5-(7-chloro-quinolin-4-ylamino)-pentyl]-3-mercapto-propionamide
3.5.2.6 0.0097
-
 IC50: 0.0097 mM Serratia marcescens 2-(mercaptomethyl)-5-phenylpentanoic acid
3.5.2.6 0.0142
-
 IC50: 0.0142 mM Serratia marcescens N-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-3-mercapto-propionamide
3.5.2.6 0.0143
-
 IC50: 0.0143 mM Pseudomonas aeruginosa 2-benzyl-3-mercaptopropanoic acid
3.5.2.6 0.0164
-
 IC50: 0.0164 mM Serratia marcescens 2-benzyl-3-mercaptopropanoic acid