EC Number | Application | Comment | Organism |
---|---|---|---|
4.3.2.2 | additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Bacillus subtilis |
4.3.2.2 | additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Homo sapiens |
4.3.2.2 | additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Thermotoga maritima |
4.3.2.2 | additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Pyrobaculum aerophilum |
EC Number | Cloned (Comment) | Organism |
---|---|---|
4.3.2.2 | expression in Escherichia coli | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
4.3.2.2 | - |
Bacillus subtilis |
4.3.2.2 | - |
Thermotoga maritima |
4.3.2.2 | - |
Pyrobaculum aerophilum |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.3.2.2 | D422Y | mutant without enzyme activity | Homo sapiens |
4.3.2.2 | D430N | mutant without enzyme activity | Homo sapiens |
4.3.2.2 | L423V | mutant without enzyme activity | Homo sapiens |
4.3.2.2 | P110A/D422Y | heat sensitive mutant | Homo sapiens |
4.3.2.2 | R141W | thermostable mutant with decreased activity | Homo sapiens |
4.3.2.2 | R303C | thermostable mutant with decreased activity | Homo sapiens |
4.3.2.2 | R426H | mutant without enzyme activity | Homo sapiens |
4.3.2.2 | S395R | thermostable mutant with decreased activity | Homo sapiens |
4.3.2.2 | S438P | heat sensitive mutant without enzyme activity | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.3.2.2 | additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Bacillus subtilis | |
4.3.2.2 | additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Homo sapiens | |
4.3.2.2 | additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Pyrobaculum aerophilum | |
4.3.2.2 | additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Thermotoga maritima | |
4.3.2.2 | nonenal | - |
Bacillus subtilis | |
4.3.2.2 | nonenal | - |
Homo sapiens | |
4.3.2.2 | nonenal | - |
Pyrobaculum aerophilum | |
4.3.2.2 | nonenal | - |
Thermotoga maritima | |
4.3.2.2 | trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Bacillus subtilis | |
4.3.2.2 | trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Homo sapiens | |
4.3.2.2 | trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Pyrobaculum aerophilum | |
4.3.2.2 | trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Thermotoga maritima |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.3.2.2 | 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Bacillus subtilis | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
4.3.2.2 | 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Homo sapiens | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
4.3.2.2 | 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Thermotoga maritima | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
4.3.2.2 | 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Pyrobaculum aerophilum | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
4.3.2.2 | adenylosuccinate | Bacillus subtilis | - |
AMP + fumarate | - |
? | |
4.3.2.2 | adenylosuccinate | Homo sapiens | - |
AMP + fumarate | - |
? | |
4.3.2.2 | adenylosuccinate | Thermotoga maritima | - |
AMP + fumarate | - |
? | |
4.3.2.2 | adenylosuccinate | Pyrobaculum aerophilum | - |
AMP + fumarate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.3.2.2 | Bacillus subtilis | - |
- |
- |
4.3.2.2 | Homo sapiens | - |
- |
- |
4.3.2.2 | Pyrobaculum aerophilum | - |
- |
- |
4.3.2.2 | Thermotoga maritima | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.3.2.2 | 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Bacillus subtilis | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
4.3.2.2 | 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Homo sapiens | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
4.3.2.2 | 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Thermotoga maritima | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
4.3.2.2 | 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Pyrobaculum aerophilum | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
4.3.2.2 | adenylosuccinate | - |
Bacillus subtilis | AMP + fumarate | - |
? | |
4.3.2.2 | adenylosuccinate | - |
Homo sapiens | AMP + fumarate | - |
? | |
4.3.2.2 | adenylosuccinate | - |
Thermotoga maritima | AMP + fumarate | - |
? | |
4.3.2.2 | adenylosuccinate | - |
Pyrobaculum aerophilum | AMP + fumarate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
4.3.2.2 | homotetramer | - |
Bacillus subtilis |
4.3.2.2 | homotetramer | - |
Homo sapiens |
4.3.2.2 | homotetramer | - |
Thermotoga maritima |
4.3.2.2 | homotetramer | - |
Pyrobaculum aerophilum |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.3.2.2 | ADSL | - |
Bacillus subtilis |
4.3.2.2 | ADSL | - |
Thermotoga maritima |
4.3.2.2 | ADSL | - |
Pyrobaculum aerophilum |