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Literature summary extracted from
- Ionization state of pyridoxal 5'-phosphate in d-serine dehydratase, dialkylglycine decarboxylase and tyrosine phenol-lyase and the influence of monovalent cations as inferred by (31)P NMR spectroscopy (2006), Biochim. Biophys. Acta, 1764, 230-238.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.64 | Na+ | - |
Burkholderia cepacia |  |
| 4.3.1.18 | Isoserine | - |
Escherichia coli | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.64 | K+ | activates | Burkholderia cepacia | |
| 4.1.1.64 | NH4+ | activates | Burkholderia cepacia | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.64 | 46500 | - |
4 * 46500, SDS-PAGE | Burkholderia cepacia |
| 4.3.1.18 | 47920 | - |
1 * 47920, calculated from amino acid sequence | Escherichia coli |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.3.1.18 | D-serine | Escherichia coli | - |
pyruvate + NH3 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.64 | Burkholderia cepacia | - |
- |
- |
| 4.1.99.2 | Citrobacter freundii | - |
- |
- |
| 4.3.1.18 | Escherichia coli | P00926 | K12 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.64 | 2-aminoisobutyrate + pyruvate | - |
Burkholderia cepacia | L-Ala + acetone + CO2 | - |
? | |
| 4.1.1.64 | Isovaline + pyruvate | - |
Burkholderia cepacia | L-Ala + butanone + CO2 | - |
? | |
| 4.3.1.18 | D-serine | - |
Escherichia coli | pyruvate + NH3 | - |
? | |
| 4.3.1.18 | D-serine | 25°C | Escherichia coli | pyruvate + NH3 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.64 | tetramer | 4 * 46500, SDS-PAGE | Burkholderia cepacia |
| 4.3.1.18 | monomer | 1 * 47920, calculated from amino acid sequence | Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.64 | DGD | - |
Burkholderia cepacia |
| 4.1.1.64 | dialkylglycine decarboxylase | - |
Burkholderia cepacia |
| 4.3.1.18 | D-serine dehydratase | - |
Escherichia coli |
| 4.3.1.18 | DSD | - |
Escherichia coli |
| 4.3.1.18 | EC 4.2.1.14 | formerly | Escherichia coli |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.64 | 8.5 | - |
- |
Burkholderia cepacia |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.99.2 | pyridoxal 5'-phosphate | the phosphate group changes from being monoanionic at low pH to dianionic at high pH | Citrobacter freundii | |
| 4.3.1.18 | pyridoxal 5'-phosphate | - |
Escherichia coli | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.3.1.18 | 0.46 | - |
Isoserine | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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