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Literature summary extracted from

  • Shaonan, L.; Xianchuan, X.; Guonian, Z.; Yajun, T.
    Kinetic characters and resistance to inhibition of crude and purified brain acetylcholinesterase of three freshwater fishes by organophosphates (2004), Aquat. Toxicol., 68, 293-299.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 Acetylcholine substrate inhibition above 1 mM Carassius auratus auratus
3.1.1.7 Acetylcholine substrate inhibition above 1 mM, less pronounced than in Pseudorasbora parva or Carassius auratus auratus Oncorhynchus mykiss
3.1.1.7 Acetylcholine substrate inhibition above 1 mM Pseudorasbora parva
3.1.1.7 oxidized malathion 50% inhibition at 0.216 mM Carassius auratus auratus
3.1.1.7 oxidized malathion 50% inhibition at 0.203 mM Oncorhynchus mykiss
3.1.1.7 oxidized malathion 50% inhibition at 0.248 mM Pseudorasbora parva
3.1.1.7 oxidized triazophos 50% inhibition at 0.043 mM Carassius auratus auratus
3.1.1.7 oxidized triazophos 50% inhibition at 0.036 mM Oncorhynchus mykiss
3.1.1.7 oxidized triazophos 50% inhibition at 0.043 mM Pseudorasbora parva

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.7 0.11
-
 Acetylcholine pH 8.1, 30°C Pseudorasbora parva
3.1.1.7 0.114
-
 Acetylcholine pH 8.1, 30°C Oncorhynchus mykiss
3.1.1.7 0.12
-
 Acetylcholine pH 8.1, 30°C Carassius auratus auratus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Carassius auratus auratus
-
-
-
3.1.1.7 Oncorhynchus mykiss
-
-
-
3.1.1.7 Pseudorasbora parva
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.7
-
 Oncorhynchus mykiss
3.1.1.7
-
 Pseudorasbora parva
3.1.1.7
-
 Carassius auratus auratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 brain
-
 Oncorhynchus mykiss
-
3.1.1.7 brain
-
 Pseudorasbora parva
-
3.1.1.7 brain
-
 Carassius auratus auratus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.7 187
-
 pH 8.1, 30°C Oncorhynchus mykiss
3.1.1.7 224.1
-
 pH 8.1, 30°C Carassius auratus auratus
3.1.1.7 236.2
-
 pH 8.1, 30°C Pseudorasbora parva

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
 Oncorhynchus mykiss choline + acetate
-
 ?
3.1.1.7 acetylcholine + H2O
-
 Pseudorasbora parva choline + acetate
-
 ?
3.1.1.7 acetylcholine + H2O
-
 Carassius auratus auratus choline + acetate
-
 ?