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Literature summary extracted from
- Purification of serine racemase: biosynthesis of the neuromodulator D-serine (1999), Proc. Natl. Acad. Sci. USA, 96, 721-725.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 5.1.1.18 | 4°C, stable for at least 4 days | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.18 | amino-oxyacetic acid | - |
Rattus norvegicus |  |
| 5.1.1.18 | hydroxylamine | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.1.18 | 10 | - |
L-serine | pH 8.0, 37°C | Rattus norvegicus | |
| 5.1.1.18 | 60 | - |
D-serine | pH 8.0, 37°C | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.1.1.18 | soluble | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.18 | 37000 | - |
x * 37000, SDS-PAGE | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.1.1.18 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.1.1.18 | cerebral cortex | glial culture from | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.18 | 0.083 | - |
pH 8.0, 37°C | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.18 | D-serine | - |
Rattus norvegicus | L-serine | - |
? | |
| 5.1.1.18 | L-serine | - |
Rattus norvegicus | D-serine | highly selctive toward L-serine | ? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.1.1.18 | ? | x * 37000, SDS-PAGE | Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.18 | 37 | - |
- |
Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.18 | 7 | - |
10% of maximum activity | Rattus norvegicus |
| 5.1.1.18 | 8 | 9 | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.18 | pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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