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Literature summary extracted from

  • Lodeiro, S.; Wilson, W.K.; Shan, H.; Matsuda, S.P.
    A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants (2006), Org. Lett., 8, 439-442.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.7 expression in yeast strains RXY6 and SMY8 Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
5.4.99.7 Y510F produces lanosterol and isomalabaricatrienol in a 95:5 ratio in strain RXY6, while in strain SMY8, the ratio is 10:90 Saccharomyces cerevisiae
5.4.99.7 Y510H incomplete cyclization, produces achilleol (45%), lanosterol (42%), parkeol (9%), and isomalabaricatrienol (4%) Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.7 (S)-2,3-oxidosqualene Saccharomyces cerevisiae
-
 lanosterol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.7 (S)-2,3-oxidosqualene
-
 Saccharomyces cerevisiae lanosterol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.7 lanosterol synthase
-
 Saccharomyces cerevisiae