EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.74 | dCTP | feedback inhibition | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.74 | additional information | - |
additional information | steady-state fluorescent measurements, substrate binding constants, recombinant enzyme | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.74 | Mg2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.74 | ATP + 2'-deoxyadenosine | Homo sapiens | - |
ADP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + 2'-deoxycytidine | Homo sapiens | - |
ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + 2'-deoxyguanosine | Homo sapiens | - |
ADP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
2.7.1.74 | additional information | Homo sapiens | enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview | ? | - |
? | |
2.7.1.74 | UTP + 2'-deoxyadenosine | Homo sapiens | - |
UDP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + 2'-deoxycytidine | Homo sapiens | preferred donor and acceptor substrates | UDP + 2'-deoxycytidine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + 2'-deoxyguanosine | Homo sapiens | - |
UDP + 2'-deoxyguanosine 5'-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.74 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.74 | ATP + 2'-deoxyadenosine | - |
Homo sapiens | ADP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + 2'-deoxycytidine | - |
Homo sapiens | ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + 2'-deoxyguanosine | - |
Homo sapiens | ADP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + adenosine | - |
Homo sapiens | ADP + adenosine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + arabinosyl cytosine | i.e. cytosar | Homo sapiens | ADP + arabinosyl cytosine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + cladribine | - |
Homo sapiens | ADP + cladribine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + cytidine | - |
Homo sapiens | ADP + cytidine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + fludarabine | - |
Homo sapiens | ADP + fludarabine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + gemcitabine | - |
Homo sapiens | ADP + gemcitabine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + L-2',3'-dideoxy-3'-thiacytidine | - |
Homo sapiens | ADP + L-2',3'-dideoxy-3'-thiacytidine 5'-phosphate | - |
? | |
2.7.1.74 | additional information | enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview | Homo sapiens | ? | - |
? | |
2.7.1.74 | additional information | broad substrate specificity, overview, binding of acceptor subtrates is more tightly in presence of phosphate donor molecules | Homo sapiens | ? | - |
? | |
2.7.1.74 | UTP + 2'-deoxyadenosine | - |
Homo sapiens | UDP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + 2'-deoxycytidine | preferred donor and acceptor substrates | Homo sapiens | UDP + 2'-deoxycytidine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + 2'-deoxyguanosine | - |
Homo sapiens | UDP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + adenosine | - |
Homo sapiens | UDP + adenosine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + arabinosyl cytosine | i.e. cytosar | Homo sapiens | UDP + arabinosyl cytosine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + cladribine | - |
Homo sapiens | UDP + cladribine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + cytidine | - |
Homo sapiens | UDP + cytidine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + fludarabine | - |
Homo sapiens | UDP + fludarabine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + gemcitabine | - |
Homo sapiens | UDP + gemcitabine 5'-phosphate | - |
? | |
2.7.1.74 | UTP + L-2',3'-dideoxy-3'-thiacytidine | - |
Homo sapiens | UDP + L-2',3'-dideoxy-3'-thiacytidine 5'-phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.74 | dCK | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.74 | ATP | - |
Homo sapiens | |
2.7.1.74 | UTP | preferred phosphate donor | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.74 | additional information | - |
additional information | steady-state fluorescent measurement, inhibitor binding constant, recombinant enzyme | Homo sapiens |