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Literature summary extracted from

  • Munier-Lehmann, H.; Pochet, S.; Dugue, L.; Dutruel, O.; Labesse, G.; Douget, D.
    Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors (2003), Nucleosides Nucleotides Nucleic Acids, 22, 801-804.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.9 2'-deoxy-5-(hydroxymethyl)uridine
-
Mycobacterium tuberculosis
2.7.4.9 2'-deoxy-5-(trifluoromethyl)uridine
-
Mycobacterium tuberculosis
2.7.4.9 2'-deoxy-5-ethyluridine
-
Mycobacterium tuberculosis
2.7.4.9 2'-deoxy-5-fluorouridine
-
Mycobacterium tuberculosis
2.7.4.9 2'-deoxy-5-hydroxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 3'-azido-2',3'-dideoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 3'-azido-3'-deoxythymidine
-
Mycobacterium tuberculosis
2.7.4.9 3'-azido-5-bromo-2',3'-dideoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 3'-azido-5-chloro-2',3'-dideoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 5'-amino-5'-deoxythymidine
-
Mycobacterium tuberculosis
2.7.4.9 5'-azido-5'-deoxythymidine
-
Mycobacterium tuberculosis
2.7.4.9 5'-deoxy-5'-(methylamino)thymidine
-
Mycobacterium tuberculosis
2.7.4.9 5'-Deoxythymidine
-
Mycobacterium tuberculosis
2.7.4.9 5'-O-methylthymidine
-
Mycobacterium tuberculosis
2.7.4.9 5-bromo-2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 5-chloro-2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 5-iodo-2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 5-[(E)-2-bromoethenyl]-2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 thymidine
-
Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.9 ATP + dTMP Mycobacterium tuberculosis involved in dTTP metabolism, essential for cell proliferation ADP + dTDP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.9 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.9 ATP + dTMP
-
Mycobacterium tuberculosis ADP + dTDP
-
?
2.7.4.9 ATP + dTMP involved in dTTP metabolism, essential for cell proliferation Mycobacterium tuberculosis ADP + dTDP
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.9 TMPK
-
Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.4.9 0.004
-
5'-Deoxythymidine
-
Mycobacterium tuberculosis
2.7.4.9 0.005
-
5-bromo-2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 0.0073
-
5'-azido-5'-deoxythymidine
-
Mycobacterium tuberculosis
2.7.4.9 0.01
-
5-chloro-2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 0.0105
-
3'-azido-5-bromo-2',3'-dideoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 0.012
-
5'-amino-5'-deoxythymidine
-
Mycobacterium tuberculosis
2.7.4.9 0.013
-
5'-deoxy-5'-(methylamino)thymidine
-
Mycobacterium tuberculosis
2.7.4.9 0.016
-
3'-azido-5-chloro-2',3'-dideoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 0.027
-
thymidine
-
Mycobacterium tuberculosis
2.7.4.9 0.028
-
3'-azido-3'-deoxythymidine
-
Mycobacterium tuberculosis
2.7.4.9 0.033
-
5-iodo-2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 0.071
-
5'-O-methylthymidine
-
Mycobacterium tuberculosis
2.7.4.9 0.212
-
2'-deoxy-5-fluorouridine
-
Mycobacterium tuberculosis
2.7.4.9 0.27
-
2'-deoxy-5-hydroxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 0.625
-
5-[(E)-2-bromoethenyl]-2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 0.81
-
3'-azido-2',3'-dideoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 0.82
-
2'-deoxy-5-(hydroxymethyl)uridine
-
Mycobacterium tuberculosis
2.7.4.9 1.02
-
2'-deoxyuridine
-
Mycobacterium tuberculosis
2.7.4.9 1.14
-
2'-deoxy-5-ethyluridine
-
Mycobacterium tuberculosis