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Literature summary extracted from

  • Spitaler, M.; Cantrell, D.A.
    Protein kinase C and beyond (2004), Nat. Immunol., 5, 785-790.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.13 diacylglycerol binds to C1 domain of PKC, regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta, overview Mus musculus
2.7.11.13 diacylglycerol binds to C1 domain of PKC, regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta, overview Homo sapiens
2.7.11.13 additional information activation mechanism of isozymes, overview Mus musculus
2.7.11.13 additional information activation mechanism of isozymes, overview Homo sapiens
2.7.11.13 phorbol 12,13-dibutyrate
-
 Mus musculus
2.7.11.13 phorbol 12,13-dibutyrate
-
 Homo sapiens
2.7.11.13 phorbol 12-myristate 13-acetate
-
 Mus musculus
2.7.11.13 phorbol 12-myristate 13-acetate
-
 Homo sapiens
2.7.11.13 Phospholipids regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta Mus musculus
2.7.11.13 Phospholipids regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.13 additional information construction of isozyme PKCtheta T-cell knockout mice, which show slightly impaired immune system and are defective in NF-kappaB activation, overview, isozyme PKCdelta knockout mice show a deregulated immune system, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.13 bisindolylmaleimide derivatives
-
 Homo sapiens
2.7.11.13 bisindolylmaleimide derivatives
-
 Mus musculus
2.7.11.13 rottlerin inhibits PKCdelta Homo sapiens
2.7.11.13 rottlerin inhibits PKCdelta Mus musculus
2.7.11.13 staurosporine PKC inhibitory alkaloid isolated from the bacterium Lentzea albida, formerly Streptomyces staurosporeus Homo sapiens
2.7.11.13 staurosporine PKC inhibitory alkaloid isolated from the bacterium Lentzea albida, formerly Streptomyces staurosporeus Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.13 additional information isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 Mus musculus
-
-
2.7.11.13 additional information isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 Homo sapiens
-
-
2.7.11.13 plasma membrane PKC is recruited by other kinases Mus musculus 5886
-
2.7.11.13 plasma membrane PKC is recruited by other kinases Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.13 Ca2+ binds to C2 domain of PKC, regulatory fucntion for isozymes alpha, betaI, betaII, and gamma, overview Homo sapiens
2.7.11.13 Ca2+ binds to C2 domain of PKC, regulatory function for isozymes alpha, betaI, betaII, and gamma, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.13 ATP + phosphoinositide-dependent kinase Mus musculus phosphoinositide-dependent kinases are conserved substrates of PKC ADP + phosphorylated phosphoinositide-dependent kinase
-
 ?
2.7.11.13 ATP + phosphoinositide-dependent kinase Homo sapiens phosphoinositide-dependent kinases are conserved substrates of PKC ADP + phosphorylated phosphoinositide-dependent kinase
-
 ?
2.7.11.13 additional information Solanum lycopersicum PKC isozymes are involved in signal transduction, required for defense against fungal infection ?
-
 ?
2.7.11.13 additional information Caenorhabditis elegans PKC isozymes are involved in signal transduction, required for host defense ?
-
 ?
2.7.11.13 additional information Homo sapiens PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 ?
-
 ?
2.7.11.13 additional information Mus musculus PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKCdelta acts as negative regulator by feedback inhibition of the CDgamma3 subunit important for immune response in T lymphocytes, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Caenorhabditis elegans
-
 multiple isozymes: classical isozymes alpha, betaI, betaII, and gamma, novel isozymes delta, epsilon, eta, and theta
-
2.7.11.13 Homo sapiens
-
 multiple isozymes: classical isozymes alpha, betaI, betaII, and gamma, novel isozymes delta, epsilon, eta, and theta, and atypical isozymes zeta and jota
-
2.7.11.13 Mus musculus
-
 multiple isozymes: classical isozymes alpha, betaI, betaII, and gamma, novel isozymes delta, epsilon, eta, and theta, and atypical isozymes zeta and lambda
-
2.7.11.13 Solanum lycopersicum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.13 B-lymphocyte
-
 Mus musculus
-
2.7.11.13 B-lymphocyte
-
 Homo sapiens
-
2.7.11.13 plant
-
 Solanum lycopersicum
-
2.7.11.13 T-lymphocyte
-
 Mus musculus
-
2.7.11.13 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 ATP + phosphoinositide-dependent kinase phosphoinositide-dependent kinases are conserved substrates of PKC Mus musculus ADP + phosphorylated phosphoinositide-dependent kinase
-
 ?
2.7.11.13 ATP + phosphoinositide-dependent kinase phosphoinositide-dependent kinases are conserved substrates of PKC Homo sapiens ADP + phosphorylated phosphoinositide-dependent kinase
-
 ?
2.7.11.13 ATP + phosphoinositide-dependent kinase i.e. PDK, phosphorylation at Ser744 and Ser748 in the activation loop of the catalytic domain of PKD Mus musculus ADP + phosphorylated phosphoinositide-dependent kinase
-
 ?
2.7.11.13 ATP + phosphoinositide-dependent kinase i.e. PDK, phosphorylation at Ser744 and Ser748 in the activation loop of the catalytic domain of PKD, reaction is regulated by diacylglycerol Homo sapiens ADP + phosphorylated phosphoinositide-dependent kinase
-
 ?
2.7.11.13 additional information PKC isozymes are involved in signal transduction, required for defense against fungal infection Solanum lycopersicum ?
-
 ?
2.7.11.13 additional information PKC isozymes are involved in signal transduction, required for host defense Caenorhabditis elegans ?
-
 ?
2.7.11.13 additional information PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 Homo sapiens ?
-
 ?
2.7.11.13 additional information PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKCdelta acts as negative regulator by feedback inhibition of the CDgamma3 subunit important for immune response in T lymphocytes, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 Mus musculus ?
-
 ?
2.7.11.13 additional information regulatory interactions of isozymes with other kinases, overview Mus musculus ?
-
 ?
2.7.11.13 additional information regulatory interactions of isozymes with other kinases, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKC
-
 Mus musculus
2.7.11.13 PKC
-
 Homo sapiens
2.7.11.13 PKC
-
 Caenorhabditis elegans
2.7.11.13 PKC-like kinase
-
 Solanum lycopersicum

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.13 ATP
-
 Mus musculus
2.7.11.13 ATP
-
 Homo sapiens