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Literature summary extracted from

  • Neve, K.A.
    Novel features of G protein-coupled receptor kinase 4 (2006), Mol. Pharmacol., 69, 673-676.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.16 co-expression of isozyme GRK4gamma and dopamine D1 receptor in HEK-293 cells leads to phosphorylation of the receptor by GRK4, this effect is not seen with isozyme GRK4beta and GRK4delta Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.16 A142V expression of the GRK4gamma mutant in transgenic mice leads to development of hypertension and lack of D1 agonist-induced diuresis and natriuresis in the mice Homo sapiens
2.7.11.16 R65L/A142V/A486V co-expression in CHO cells with the dopamine D1 receptor causes enhanced desensitization and agonist-independent phosphorylation of the receptor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.16 membrane anchoring of GRK4 by palmitoyl residue at the C-terminus Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.16 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.16 ATP + [dopamine D1 receptor] Homo sapiens GRK4 constitutively phosphorylates active and inactive receptor, in the latter case diminishing stimulation of the receptor by dopamine, phosphorylation reduces receptor desensitization and internalization, followed by reduced cAMP accumulation ADP + [dopamine D1 receptor]phosphate
-
 ?
2.7.11.16 ATP + [G protein-coupled receptor] Homo sapiens GRK4-6 ADP + [G protein-coupled receptor]phosphate
-
 ?
2.7.11.16 additional information Homo sapiens the GRK4 isozymes are differentially regulated, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.16 Homo sapiens
-
 4 splicing variants of GRK4, i.e. GRK4alpha, GRK4beta, GRK4gamma, and GRK4delta, overview
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.16 lipoprotein GRK4 is palmitoylated at the C-terminus Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.16 ATP + [beta2-adrenergic receptor] GRK4-6 Homo sapiens ADP + [beta2-adrenergic receptor]phosphate
-
 ?
2.7.11.16 ATP + [dopamine D1 receptor] GRK4 constitutively phosphorylates active and inactive receptor, in the latter case diminishing stimulation of the receptor by dopamine, phosphorylation reduces receptor desensitization and internalization, followed by reduced cAMP accumulation Homo sapiens ADP + [dopamine D1 receptor]phosphate
-
 ?
2.7.11.16 ATP + [dopamine D1 receptor] GRK4 phosphorylates active and inactive receptor Homo sapiens ADP + [dopamine D1 receptor]phosphate
-
 ?
2.7.11.16 ATP + [follicle-stimulating hormone receptor] GRK4-6 Homo sapiens ADP + [follicle-stimulating hormone receptor]phosphate
-
 ?
2.7.11.16 ATP + [G protein-coupled receptor] GRK4-6 Homo sapiens ADP + [G protein-coupled receptor]phosphate
-
 ?
2.7.11.16 ATP + [luteinizing hormone/chorionic gonadotropin receptor] GRK4-6 Homo sapiens ADP + [luteinizing hormone/chorionic gonadotropin receptor]phosphate
-
 ?
2.7.11.16 ATP + [M2 muscarinic receptor] GRK4-6 Homo sapiens ADP + [M2 muscarinic receptor]phosphate
-
 ?
2.7.11.16 ATP + [rhodopsin] GRK4-6 Homo sapiens ADP + [rhodopsin]phosphate
-
 ?
2.7.11.16 additional information the GRK4 isozymes are differentially regulated, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.16 G protein-coupled receptor kinase 4
-
 Homo sapiens
2.7.11.16 GRK4
-
 Homo sapiens
2.7.11.16 More GRK4 belongs to the GRK4 subfamily of the GRK family Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.16 ATP
-
 Homo sapiens