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Literature summary extracted from

  • Yoon, C.S.; Kim, D.W.; Jang, S.H.; Lee, B.R.; Choi, H.S.; Choi, S.H.; Kim, S.Y.; An, J.J.; Kwon, O.S.; Kang, T.C.; Won, M.H.; Cho, S.W.; Lee, K.S.; Park, J.; Eum, W.S.; Choi, S.Y.
    Cysteine-321 of human brain GABA transaminase is involved in intersubunit cross-linking (2004), Mol. Cells, 18, 214-219.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.6.1.19 C321M no enzymic activity, behaves as monomer even in absence of 2-mercaptoethanol Homo sapiens
2.6.1.19 C321S no enzymic activity, behaves as monomer even in absence of 2-mercaptoethanol Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 5,5'-dithiobis-2-nitrobenzoic acid 95% loss of activity Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.19 50000
-
2 * 50000, SDS-PAGE, presence of 2-mercaptoethanol Homo sapiens
2.6.1.19 100000
-
SDS-PAGE, absence of 2-mercaptoethanol Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 brain
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.19 17.5
-
pH 8.4, 25°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
Homo sapiens 4-oxobutanoate + L-glutamate
-
?

Subunits

EC Number Subunits Comment Organism
2.6.1.19 dimer 2 * 50000, SDS-PAGE, presence of 2-mercaptoethanol Homo sapiens