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Literature summary extracted from

  • Kenyon, T.K.; Homan, E.; Storlie, J.; Ikoma, M.; Grose, C.
    Comparison of varicella-zoster virus ORF47 protein kinase and casein kinase II and their substrates (2003), J. Med. Virol., 70 Suppl 1, S95-102.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.1 putrescine aliphatic, positively charged polyamine, required for in vitro activity of ORF47, polyamine depletion leads to 80% reduced activity Human alphaherpesvirus 3
2.7.11.1 spermidine aliphatic, positively charged polyamine, required for in vitro activity of ORF47, polyamine depletion leads to 80% reduced activity Human alphaherpesvirus 3
2.7.11.1 spermine aliphatic, positively charged polyamine, required for in vitro activity of ORF47, polyamine depletion leads to 80% reduced activity Human alphaherpesvirus 3

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 heparin strongly inhibits casein kinase II Homo sapiens
2.7.11.1 additional information ORF47 kinase is resistant to heparin, host cell pretreatment prior to virus infection with D,L-alpha-difluoromethylornithine reduces intracellular polyamine concentration and thus inhibits the viral enzyme ORF47 Human alphaherpesvirus 3

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens
-
-
-
2.7.11.1 Human alphaherpesvirus 3
-
 VZV-32, propagated in MeWo human melanoma cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 HeLa cell
-
 Homo sapiens
-
2.7.11.1 melanoma cell
-
 Homo sapiens
-
2.7.11.1 MeWo cell melanoma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + casein
-
 Human alphaherpesvirus 3 ADP + phosphorylated casein
-
 ?
2.7.11.1 ATP + IgG2A heavy chain substrate protein from mouse Human alphaherpesvirus 3 ADP + phosphorylated IgG2A heavy chain
-
 ?
2.7.11.1 ATP + maltose-binding protein
-
 Human alphaherpesvirus 3 ADP + phosphorylated maltose-binding protein
-
 ?
2.7.11.1 ATP + ORF62 protein protein substrate from Varicella-Zoster virus, no activity with a truncated ORF62 mutant Human alphaherpesvirus 3 ADP + ORF62 phosphoprotein
-
 ?
2.7.11.1 ATP + ORF63 protein protein substrate from Varicella-Zoster virus Human alphaherpesvirus 3 ADP + ORF63 phosphoprotein
-
 ?
2.7.11.1 ATP + Varicella-Zoster viral gB protein phosphorylation at S34 in the sequence QSEDIT Homo sapiens ADP + phosphorylated Varicella-Zoster viral gB protein
-
 ?
2.7.11.1 additional information CKII phosphorylates serine or threonine residues with an acidic amino acid in the +2 or +3 position Homo sapiens ?
-
 ?
2.7.11.1 additional information the minimal consensus sequence of ORF47 is S/T-X-D/E-D/E, no activity of ORF47 with glutathione S-transferase, or Varicella-Zoster viral gB protein Human alphaherpesvirus 3 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 casein kinase II
-
 Homo sapiens
2.7.11.1 CKII
-
 Homo sapiens
2.7.11.1 ORF47 protein
-
 Human alphaherpesvirus 3

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.1 ATP
-
 Human alphaherpesvirus 3