EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.4.9 | drug development | potential target for the development of new antituberculosis drugs due to the low sequence similarity with the human enzyme | Mycobacterium tuberculosis |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.4.9 | expressed in Escherichia coli | Homo sapiens |
2.7.4.9 | expressed in Escherichia coli | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.9 | 1,3-bis[[(2S,3R,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea | - |
Homo sapiens | |
2.7.4.9 | 1,3-bis[[(2S,3R,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Homo sapiens | |
2.7.4.9 | 1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Homo sapiens | |
2.7.4.9 | 1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 2',5'-difluoro-3'-azidomethylthymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 2'-chlorothymidine 5'-monophosphate | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 2'-fluorothymidine 5'-monophosphate | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-(aminomethyl)-2'-chloro-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-(aminomethyl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.4.9 | 3'-(aminomethyl)-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-(azidomethyl)-2'-chloro-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-(azidomethyl)-3'-deoxy-2'-fluorothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-(azidomethyl)-3'-deoxy-alpha-D-ribosyl-thymine | - |
Homo sapiens | |
2.7.4.9 | 3'-(azidomethyl)-3'-deoxy-alpha-D-ribosyl-thymine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-(azidomethyl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.4.9 | 3'-(azidomethyl)-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-azido-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-azido-3'-deoxythymidine 5'-monophosphate | potential inhibitor of the bacterial enzyme, not inhibitory in human | Mycobacterium tuberculosis | |
2.7.4.9 | 3'-azido-3'-deoxythymidine 5'-phosphate | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-deoxythymidine 5'-monophosphate | - |
Mycobacterium tuberculosis | |
2.7.4.9 | dTMP | - |
Homo sapiens | |
2.7.4.9 | dTMP | - |
Mycobacterium tuberculosis | |
2.7.4.9 | additional information | 3-azido-3-deoxythymidine monophosphate is not inhibitory, various thymine derivatives tested and found to inhibit activity to different extents | Homo sapiens | |
2.7.4.9 | additional information | 3'-(aminomethyl)-3'-deoxy-2'-fluorothymidine is not inhibitory at 1 mM; 3-azido-3-deoxythymidine monophosphate is not inhibitory, various thymine derivatives tested and found to inhibit activity to different extents | Mycobacterium tuberculosis | |
2.7.4.9 | thymidine | - |
Homo sapiens | |
2.7.4.9 | thymidine | - |
Mycobacterium tuberculosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.9 | 0.0045 | - |
dTMP | pH 7.4 | Mycobacterium tuberculosis | |
2.7.4.9 | 0.005 | - |
dTMP | pH 7.4 | Homo sapiens | |
2.7.4.9 | 0.012 | - |
3'-azido-3'-deoxythymidine monophosphate | pH 7.4 | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.9 | Mg2+ | bound to enzyme, displacement of Mg2+ might be responsible for inhibitory effect of the enzyme inhibitors | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.9 | ATP + dTMP | Homo sapiens | involved in dTTP metabolism, essential for cell proliferation | ADP + dTDP | - |
? | |
2.7.4.9 | ATP + dTMP | Mycobacterium tuberculosis | involved in dTTP metabolism, essential for cell proliferation | ADP + dTDP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.4.9 | Homo sapiens | - |
- |
- |
2.7.4.9 | Mycobacterium tuberculosis | P9WKE1 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.9 | ATP + 3'-azido-3'-deoxythymidine monophosphate | - |
Homo sapiens | ADP + 3'-azido-3'-deoxythymidine diphosphate | - |
? | |
2.7.4.9 | ATP + dTMP | - |
Homo sapiens | ADP + dTDP | - |
? | |
2.7.4.9 | ATP + dTMP | - |
Mycobacterium tuberculosis | ADP + dTDP | - |
? | |
2.7.4.9 | ATP + dTMP | involved in dTTP metabolism, essential for cell proliferation | Homo sapiens | ADP + dTDP | - |
? | |
2.7.4.9 | ATP + dTMP | involved in dTTP metabolism, essential for cell proliferation | Mycobacterium tuberculosis | ADP + dTDP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.4.9 | TMPK | - |
Homo sapiens |
2.7.4.9 | TMPK | - |
Mycobacterium tuberculosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.9 | 0.0035 | - |
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.0045 | - |
dTMP | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.005 | - |
dTMP | - |
Homo sapiens | |
2.7.4.9 | 0.01 | - |
3'-azido-3'-deoxythymidine 5'-phosphate | pH 7.4 | Mycobacterium tuberculosis | |
2.7.4.9 | 0.0135 | - |
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.019 | - |
2'-chlorothymidine 5'-monophosphate | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.027 | - |
thymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.029 | - |
1,3-bis[[(2S,3R,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.04 | - |
3'-(azidomethyl)-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.043 | - |
2'-fluorothymidine 5'-monophosphate | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.057 | - |
3'-(aminomethyl)-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.08 | - |
2',5'-difluoro-3'-azidomethylthymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.165 | - |
3'-(azidomethyl)-3'-deoxy-2'-fluorothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.18 | - |
thymidine | - |
Homo sapiens | |
2.7.4.9 | 0.18 | - |
3'-(azidomethyl)-2'-chloro-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.22 | - |
3'-(aminomethyl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.4.9 | 0.39 | - |
3'-(aminomethyl)-2'-chloro-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 0.7 | - |
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Homo sapiens | |
2.7.4.9 | 1.04 | - |
3'-(azidomethyl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.4.9 | 1.1 | - |
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Homo sapiens |