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Literature summary extracted from

  • Hogenboom, S.; Tuyp, J.J.; Espeel, M.; Koster, J.; Wanders, R.J.; Waterham, H.R.
    Phosphomevalonate kinase is a cytosolic protein in humans (2004), J. Lipid Res., 45, 697-705.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.2 expressed in CV-1 cells Homo sapiens
2.7.4.2 expression in human embryonic kidney (HEK-293) Flp-In and CV1 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.2 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.2 ATP + (R)-5-phosphomevalonate Homo sapiens mevalonate pathway of isopentenyl diphosphate biosynthesis ADP + (R)-5-diphosphomevalonate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.2 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.2
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.2 fibroblast endogenously expressed human phosphomevalonate kinase and overexpressed human phosphomevalonate kinase Homo sapiens
-
2.7.4.2 HEK-293 cell endogenously expressed human phosphomevalonate kinase and overexpressed human phosphomevalonate kinase Homo sapiens
-
2.7.4.2 liver endogenously expressed human phosphomevalonate kinase Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.2 ATP + (R)-5-phosphomevalonate mevalonate pathway of isopentenyl diphosphate biosynthesis Homo sapiens ADP + (R)-5-diphosphomevalonate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.2 phosphomevalonate kinase
-
 Homo sapiens
2.7.4.2 PMK
-
 Homo sapiens