EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.57 | expression in a rat epidermal cell line, enzyme overexpression in transgenic mice | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.3.1.57 | additional information | enzyme overexpression in transgenic mice leads to accumulation of purtrescine and permanent hair loss at the age of 3-weeks, because the hair follicles are exchanged for dermal cysts and epidermal utriculi due to reduced expression of terminal differentiation markers such as cytokeratins 1/10, and filaggrin, and persisting expression of basal cell cytokeratins 5/14 in the suprabasal layer, hair growth can be reactivated by reduction of putrescine content | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.57 | acetyl-CoA + spermidine | Mus musculus | - |
CoA + N1-acetylspermidine | - |
? | |
2.3.1.57 | acetyl-CoA + spermine | Mus musculus | - |
CoA + N1-acetylspermine | - |
? | |
2.3.1.57 | additional information | Mus musculus | the enzyme is rate-limiting in polyamine catabolism | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.57 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.57 | epidermis | - |
Mus musculus | - |
2.3.1.57 | keratinocyte | - |
Mus musculus | - |
2.3.1.57 | skin | - |
Mus musculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.1.57 | additional information | - |
polyamine content in different clones of a transfected rat epidermal cell line expressing the enzyme, overview | Mus musculus |
2.3.1.57 | 0.000003 | 0.00008 | activity in different clones of a transfected rat epidermal cell line expressing the enzyme | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.57 | acetyl-CoA + spermidine | - |
Mus musculus | CoA + N1-acetylspermidine | - |
? | |
2.3.1.57 | acetyl-CoA + spermine | - |
Mus musculus | CoA + N1-acetylspermine | - |
? | |
2.3.1.57 | additional information | the enzyme is rate-limiting in polyamine catabolism | Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.57 | spermidine/spermine N-acetyltransferase | - |
Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.57 | 7.4 | - |
assay at | Mus musculus |