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Literature summary extracted from

  • Sulaiman, S.A.J.; Suliman, F.E.O.; Barghouthi, S.
    Kinetic studies of the inhibition of GABA-T by gamma-vinyl GABA and taurine (2003), J. Enzyme Inhib. Med. Chem., 18, 297-301.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 4-aminohex-5-enoic acid i.e. gamma-vinyl GABA, competitive, does not affect transamination process of 2-oxoglutarate Pseudomonas fluorescens
2.6.1.19 ethylamine-2-sulfonic acid i.e. taurine, competitive Pseudomonas fluorescens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.19 0.47
-
2-oxoglutarate pH 8.6, 25°C Pseudomonas fluorescens
2.6.1.19 0.79
-
4-aminobutanoate pH 8.6, 25°C Pseudomonas fluorescens

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Pseudomonas fluorescens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
Pseudomonas fluorescens 4-oxobutanoate + L-glutamate
-
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Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.19 26
-
4-aminohex-5-enoic acid pH 8.6, 25°C Pseudomonas fluorescens
2.6.1.19 68
-
ethylamine-2-sulfonic acid pH 8.6, 25°C Pseudomonas fluorescens