BRENDA - Enzyme Database

Competitive inhibitors of Mycobacterium tuberculosis ribose-5-phosphate isomerase B reveal new information about the reaction mechanism

Roos, A.K.; Burgos, E.; Ericsson, D.J.; Salmon, L.; Mowbray, S.L.; J. Biol. Chem. 280, 6416-6422 (2005)

Data extracted from this reference:

Crystallization (Commentary)
EC Number
Crystallization
Organism
5.3.1.6
hanging drop vapour diffusion method, X-ray structure of ribose-5-phosphate isomerase B in complex with the inhibitors 4-phosphono-D-erythronohydroxamate and 4-phospho-D-erythronate refined to resolutions of 2.1 and 2.2 A
Mycobacterium tuberculosis
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.1.6
4-phospho-D-erythronate
-
Mycobacterium tuberculosis
5.3.1.6
4-phosphono-D-erythronohydroxamate
-
Mycobacterium tuberculosis
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
5.3.1.6
1.8
-
D-ribose 5-phosphate
-
Mycobacterium tuberculosis
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.1.6
Mycobacterium tuberculosis
P9WKD7
-
-
5.3.1.6
Mycobacterium tuberculosis H37Rv
P9WKD7
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.1.6
D-ribose 5-phosphate
-
662445
Mycobacterium tuberculosis
D-ribulose 5-phosphate
-
-
-
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
5.3.1.6
0.057
-
4-phosphono-D-erythronohydroxamate
-
Mycobacterium tuberculosis
5.3.1.6
1.7
-
4-phospho-D-erythronate
-
Mycobacterium tuberculosis
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
5.3.1.6
hanging drop vapour diffusion method, X-ray structure of ribose-5-phosphate isomerase B in complex with the inhibitors 4-phosphono-D-erythronohydroxamate and 4-phospho-D-erythronate refined to resolutions of 2.1 and 2.2 A
Mycobacterium tuberculosis
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.1.6
4-phospho-D-erythronate
-
Mycobacterium tuberculosis
5.3.1.6
4-phosphono-D-erythronohydroxamate
-
Mycobacterium tuberculosis
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
5.3.1.6
0.057
-
4-phosphono-D-erythronohydroxamate
-
Mycobacterium tuberculosis
5.3.1.6
1.7
-
4-phospho-D-erythronate
-
Mycobacterium tuberculosis
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
5.3.1.6
1.8
-
D-ribose 5-phosphate
-
Mycobacterium tuberculosis
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.1.6
D-ribose 5-phosphate
-
662445
Mycobacterium tuberculosis
D-ribulose 5-phosphate
-
-
-
?