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Literature summary extracted from

  • Roos, A.K.; Burgos, E.; Ericsson, D.J.; Salmon, L.; Mowbray, S.L.
    Competitive inhibitors of Mycobacterium tuberculosis ribose-5-phosphate isomerase B reveal new information about the reaction mechanism (2005), J. Biol. Chem., 280, 6416-6422.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.3.1.6 hanging drop vapour diffusion method, X-ray structure of ribose-5-phosphate isomerase B in complex with the inhibitors 4-phosphono-D-erythronohydroxamate and 4-phospho-D-erythronate refined to resolutions of 2.1 and 2.2 A Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.1.6 4-phospho-D-erythronate
-
 Mycobacterium tuberculosis
5.3.1.6 4-phosphono-D-erythronohydroxamate
-
 Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.1.6 1.8
-
 D-ribose 5-phosphate
-
 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.6 Mycobacterium tuberculosis P9WKD7
-
-
5.3.1.6 Mycobacterium tuberculosis H37Rv P9WKD7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.6 D-ribose 5-phosphate
-
 Mycobacterium tuberculosis D-ribulose 5-phosphate
-
 ?
5.3.1.6 D-ribose 5-phosphate
-
 Mycobacterium tuberculosis H37Rv D-ribulose 5-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.1.6 ribose-5-phosphate isomerase B
-
 Mycobacterium tuberculosis
5.3.1.6 RpiB
-
 Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.3.1.6 0.057
-
 4-phosphono-D-erythronohydroxamate
-
 Mycobacterium tuberculosis
5.3.1.6 1.7
-
 4-phospho-D-erythronate
-
 Mycobacterium tuberculosis