Literature summary extracted from

Orr, W.C.; Radyuk, S.N.; Prabhudesai, L.; Toroser, D.; Benes, J.J.; Luchak, J.M.; Mockett, R.J.; Rebrin, I.; Hubbard, J.G.; Sohal, R.S.
Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster (2005), J. Biol. Chem., 280, 37331-37338.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
6.3.2.2	the GAL4-UAS binary transgenic system is used to generate flies overexpressing either the catalytic (GCLc) or modulatory (GCLm) subunit of this enzyme, in a global or neuronally targeted pattern	Drosophila melanogaster

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.2.2	Drosophila melanogaster	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.2.2	additional information	enhancement of the glutathione biosynthetic capability, particularly in neuronal tissues, can extend the life span of flies	Drosophila melanogaster	?	-	?

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Release 2023.1 (January 2023)