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Literature summary extracted from

  • Essex-Fraser, P.A.; Steele, S.L.; Bernier, N.J.; Murray, B.W.; Stevens, E.D.; Wright, P.A.
    Expression of four glutamine synthetase genes in the early stages of development of rainbow trout (Oncorhynchus mykiss) in relationship to nitrogen excretion (2005), J. Biol. Chem., 280, 20268-20273.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.1.2 ATP + L-glutamate + NH4+ Oncorhynchus mykiss it is proposed that the induction of glutamine synthetase genes early in development and the subsequent formation of the active protein are preparatory for the increased capacity of the embryo to convert the toxic nitrogen end product, ammonia, into glutamine, which may then be utilized in the ornithine-urea cycle or other pathways ADP + phosphate + L-glutamine
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Organism

EC Number Organism UniProt Comment Textmining
6.3.1.2 Oncorhynchus mykiss
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.1.2 brain glutamine synthetase activity is relatively low in all adult tissues examined, except brain Oncorhynchus mykiss
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6.3.1.2 liver the four genes coding for glutamine synthetase (Onmy-GS01, Onmy-GS02, Onmy-GS03 and Onmy-GS04) are expressed during early development, but only Onmy-GS01 and GS02 are expressed at appreciable levels in adult liver Oncorhynchus mykiss
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6.3.1.2 skeletal muscle very low expression Oncorhynchus mykiss
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.2 ATP + L-glutamate + NH4+ it is proposed that the induction of glutamine synthetase genes early in development and the subsequent formation of the active protein are preparatory for the increased capacity of the embryo to convert the toxic nitrogen end product, ammonia, into glutamine, which may then be utilized in the ornithine-urea cycle or other pathways Oncorhynchus mykiss ADP + phosphate + L-glutamine
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 ?