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Literature summary extracted from

  • Nagata, E.; Luo, H.R.; Saiardi, A.; Bae, B.I.; Suzuki, N.; Snyder, S.H.
    Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death (2005), J. Biol. Chem., 280, 1634-1640.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.21 expression in HeLa cells, PC12 cells, Jurkat T cells, OVCAR-3 cells, HL-60 cells and HEK-293 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.21 mitochondrion
-
 Homo sapiens 5739
-
2.7.4.21 nucleus cytotoxicity is associated with a translocation of InsP6K2 from nuclei to mitochondria Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate Homo sapiens apoptosis regulation ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.21 HEK-293 cell
-
 Homo sapiens
-
2.7.4.21 HeLa cell
-
 Homo sapiens
-
2.7.4.21 HL-60 cell
-
 Homo sapiens
-
2.7.4.21 JURKAT cell
-
 Homo sapiens
-
2.7.4.21 OVCAR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate apoptosis regulation Homo sapiens ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.21 inositol hexakisphosphate kinase-2
-
 Homo sapiens
2.7.4.21 InsP6K2
-
 Homo sapiens