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Literature summary extracted from
- Bifunctional phosphoglucose/phosphomannose isomerases from the Archaea Aeropyrum pernix and Thermoplasma acidophilum constitute a novel enzyme family within the phosphoglucose isomerase superfamily (2004), J. Biol. Chem., 279, 2262-2272.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.1.8 | 6-phosphogluconate | - |
Aeropyrum pernix |  |
| 5.3.1.8 | 6-phosphogluconate | - |
Thermoplasma acidophilum | |
| 5.3.1.8 | erythrose 4-phosphate | - |
Aeropyrum pernix | |
| 5.3.1.8 | erythrose 4-phosphate | - |
Thermoplasma acidophilum | |
| 5.3.1.9 | 6-phosphogluconate | - |
Aeropyrum pernix | |
| 5.3.1.9 | 6-phosphogluconate | - |
Thermoplasma acidophilum | |
| 5.3.1.9 | erythrose 4-phosphate | - |
Aeropyrum pernix | |
| 5.3.1.9 | erythrose 4-phosphate | - |
Thermoplasma acidophilum | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.1.8 | 0.2 | - |
D-fructose 6-phosphate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.8 | 0.21 | - |
D-fructose 6-phosphate | 50°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.8 | 0.25 | - |
D-mannose 6-phosphate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.8 | 0.44 | - |
D-fructose 6-phosphate | 80°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.8 | 0.72 | - |
D-glucose 6-phosphate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.8 | 1.1 | - |
D-mannose 6-phosphate | 80°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.8 | 3.5 | - |
D-glucose 6-phosphate | 80°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.9 | 0.2 | - |
D-fructose 6-phosphate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.9 | 0.21 | - |
D-fructose 6-phosphate | 50°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.9 | 0.25 | - |
D-mannose 6-phosphate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.9 | 0.44 | - |
D-fructose 6-phosphate | 80°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.9 | 0.72 | - |
D-glucose 6-phosphate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.9 | 1.1 | - |
D-mannose 6-phosphate | 80°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.9 | 3.5 | - |
D-glucose 6-phosphate | 80°C, pH 7.4 | Aeropyrum pernix | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.3.1.8 | 35000 | - |
2 * 35000, SDS-PAGE, 2 * 35150, calculated | Thermoplasma acidophilum |
| 5.3.1.8 | 35150 | - |
2 * 35000, SDS-PAGE, 2 * 35150, calculated | Thermoplasma acidophilum |
| 5.3.1.8 | 36000 | - |
2 * 36000, SDS-PAGE, 2 * 36100, calculated | Aeropyrum pernix |
| 5.3.1.8 | 36100 | - |
2 * 36000, SDS-PAGE, 2 * 36100, calculated | Aeropyrum pernix |
| 5.3.1.8 | 45000 | - |
gel filtration | Aeropyrum pernix |
| 5.3.1.8 | 48000 | - |
gel filtration | Thermoplasma acidophilum |
| 5.3.1.8 | 67000 | - |
analytical ultracentrifugation | Thermoplasma acidophilum |
| 5.3.1.9 | 35000 | - |
2 * 35000, SDS-PAGE, 2 * 35150, calculated | Thermoplasma acidophilum |
| 5.3.1.9 | 35150 | - |
2 * 35000, SDS-PAGE, 2 * 35150, calculated | Thermoplasma acidophilum |
| 5.3.1.9 | 36000 | - |
2 * 36000, SDS-PAGE, 2 * 36100, calculated | Aeropyrum pernix |
| 5.3.1.9 | 36100 | - |
2 * 36000, SDS-PAGE, 2 * 36100, calculated | Aeropyrum pernix |
| 5.3.1.9 | 45000 | - |
gel filtration | Aeropyrum pernix |
| 5.3.1.9 | 48000 | - |
gel filtration | Thermoplasma acidophilum |
| 5.3.1.9 | 67000 | - |
analytical ultracentrifugation | Thermoplasma acidophilum |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.1.8 | Aeropyrum pernix | Q9YE01 | biunctional phosphoglucose/phosphomannose isomerase EC 5.3.1.9 and 5.3.1.8, resp. | - |
| 5.3.1.8 | Thermoplasma acidophilum | Q9HIC2 | biunctional phosphoglucose/phosphomannose isomerase EC 5.3.1.9 and 5.3.1.8, resp. | - |
| 5.3.1.9 | Aeropyrum pernix | Q9YE01 | biunctional phosphoglucose/phosphomannose isomerase EC 5.3.1.9 and 5.3.1.8, resp. | - |
| 5.3.1.9 | Thermoplasma acidophilum | Q9HIC2 | biunctional phosphoglucose/phosphomannose isomerase EC 5.3.1.9 and 5.3.1.8 resp. | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.1.8 | D-fructose 6-phosphate | - |
Aeropyrum pernix | D-glucose 6-phosphate | - |
r | |
| 5.3.1.8 | D-fructose 6-phosphate | - |
Thermoplasma acidophilum | D-glucose 6-phosphate | - |
r | |
| 5.3.1.8 | D-fructose 6-phosphate | - |
Aeropyrum pernix | D-mannose 6-phosphate | - |
r | |
| 5.3.1.8 | D-fructose 6-phosphate | - |
Thermoplasma acidophilum | D-mannose 6-phosphate | - |
r | |
| 5.3.1.8 | D-glucose 6-phosphate | - |
Aeropyrum pernix | D-fructose 6-phosphate | - |
r | |
| 5.3.1.8 | D-glucose 6-phosphate | - |
Thermoplasma acidophilum | D-fructose 6-phosphate | - |
r | |
| 5.3.1.8 | D-Mannose 6-phosphate | - |
Aeropyrum pernix | D-Fructose 6-phosphate | - |
r | |
| 5.3.1.8 | D-Mannose 6-phosphate | - |
Thermoplasma acidophilum | D-Fructose 6-phosphate | - |
r | |
| 5.3.1.9 | D-fructose 6-phosphate | - |
Aeropyrum pernix | D-glucose 6-phosphate | - |
r | |
| 5.3.1.9 | D-fructose 6-phosphate | - |
Thermoplasma acidophilum | D-glucose 6-phosphate | - |
r | |
| 5.3.1.9 | D-fructose 6-phosphate | - |
Aeropyrum pernix | D-mannose 6-phosphate | - |
r | |
| 5.3.1.9 | D-fructose 6-phosphate | - |
Thermoplasma acidophilum | D-mannose 6-phosphate | - |
r | |
| 5.3.1.9 | D-glucose 6-phosphate | - |
Aeropyrum pernix | D-fructose 6-phosphate | - |
r | |
| 5.3.1.9 | D-glucose 6-phosphate | - |
Thermoplasma acidophilum | D-fructose 6-phosphate | - |
r | |
| 5.3.1.9 | D-Mannose 6-phosphate | - |
Aeropyrum pernix | D-Fructose 6-phosphate | - |
r | |
| 5.3.1.9 | D-Mannose 6-phosphate | - |
Thermoplasma acidophilum | D-Fructose 6-phosphate | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.3.1.8 | dimer | 2 * 35000, SDS-PAGE, 2 * 35150, calculated | Thermoplasma acidophilum |
| 5.3.1.8 | dimer | 2 * 36000, SDS-PAGE, 2 * 36100, calculated | Aeropyrum pernix |
| 5.3.1.9 | dimer | 2 * 35000, SDS-PAGE, 2 * 35150, calculated | Thermoplasma acidophilum |
| 5.3.1.9 | dimer | 2 * 36000, SDS-PAGE, 2 * 36100, calculated | Aeropyrum pernix |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.3.1.9 | 75 | - |
- |
Thermoplasma acidophilum |
| 5.3.1.9 | 98 | - |
or above | Aeropyrum pernix |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.3.1.9 | 86 | - |
melting temperature | Thermoplasma acidophilum |
| 5.3.1.9 | 100 | - |
melting temperature above 100°C | Aeropyrum pernix |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.3.1.9 | 7.6 | - |
- |
Aeropyrum pernix |
| 5.3.1.9 | 7.6 | - |
- |
Thermoplasma acidophilum |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.1.8 | 0.035 | - |
erythrose 4-phosphate | 80°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.8 | 0.164 | - |
erythrose 4-phosphate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.8 | 2 | 10 | 6-phosphogluconate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.8 | 58 | - |
6-phosphogluconate | 80°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.9 | 0.035 | - |
erythrose 4-phosphate | 80°C, pH 7.4 | Aeropyrum pernix | |
| 5.3.1.9 | 0.164 | - |
erythrose 4-phosphate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.9 | 2 | 10 | 6-phosphogluconate | 80°C, pH 7.4 | Thermoplasma acidophilum | |
| 5.3.1.9 | 58 | - |
6-phosphogluconate | 80°C, pH 7.4 | Aeropyrum pernix | |
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