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Literature summary extracted from

  • Lithgow, J.K.; Hayhurst, E.J.; Cohen, G.; Aharonowitz, Y.; Foster, S.J.
    Role of a cysteine synthase in Staphylococcus aureus (2004), J. Bacteriol., 186, 1579-1590.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.47 additional information enzyme knockout mutant, grows poorly in cysteine-limiting conditions and produces significantly less cysteine than wild-type. Mutant shows increased sensitivity to tellurite, hydrogen peroxide, acid, and diamide. Mutant cells have a significantly reduced ability to recover from starvation in amino acid- or phosphate-limiting conditions Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.47 O-acetyl-L-Ser + sodium thiosulfate Staphylococcus aureus
-
 ?
-
 ?
2.5.1.47 O-acetyl-L-Ser + sodium thiosulfate Staphylococcus aureus SH1000
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.47 Staphylococcus aureus
-
-
-
2.5.1.47 Staphylococcus aureus SH1000
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.47 O-acetyl-L-Ser + sodium thiosulfate
-
 Staphylococcus aureus ?
-
 ?
2.5.1.47 O-acetyl-L-Ser + sodium thiosulfate
-
 Staphylococcus aureus SH1000 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.47 CysM
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.5.1.47 malfunction mutation of cysM causes increased sensitivity of Staphylococcus (S.) aureus to tellurite (15fold), hydrogen peroxide (45fold), acid (30fold after 4h at pH 2.0), and diamide (but not methyl viologen) and also significantly reduces the ability to recover from starvation in amino acid- or phosphate-limiting conditions. A cysM knockout mutant grows poorly in cysteine-limiting conditions Staphylococcus aureus