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Literature summary extracted from

  • Gao, H.; Leary, J.A.
    Multiplex inhibitor screening and kinetic constant determinations for yeast hexokinase using mass spectrometry based assays (2003), J. Am. Soc. Mass Spectrom., 14, 173-181.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 ADP competitive versus ATP, inhibition mode, 91.3% decreased activity Saccharomyces cerevisiae
2.7.1.1 AMP 51.4% decreased activity Saccharomyces cerevisiae
2.7.1.1 CoA 54.1% decreased activity Saccharomyces cerevisiae
2.7.1.1 D-glucose 1,6-diphosphate 15.7% decreased activity Saccharomyces cerevisiae
2.7.1.1 D-glucose 6-phosphate 54.3% decreased activity Saccharomyces cerevisiae
2.7.1.1 GDP 31.3% decreased activity Saccharomyces cerevisiae
2.7.1.1 additional information multiplex inhibitor screening, mass spectrometry-based assay Saccharomyces cerevisiae
2.7.1.1 oxidized glutathione 82.9% decreased activity Saccharomyces cerevisiae
2.7.1.1 reduced glutathione 54.5% decreased activity Saccharomyces cerevisiae
2.7.1.1 trehalose 6-phosphate 90.9% decreased activity Saccharomyces cerevisiae
2.7.1.1 UDP 51.9% decreased activity Saccharomyces cerevisiae
2.7.1.1 UDP-glucose 62.5% decreased activity Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 additional information
-
additional information kinetics, mass spectrometry-based assay, overview, the Mg2+ concentration influence the kinetics Saccharomyces cerevisiae
2.7.1.1 0.1
-
ATP pH 7.5, 22°C Saccharomyces cerevisiae
2.7.1.1 0.13
-
D-glucose pH 7.5, 22°C Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.1 Mg2+
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.1 ATP + D-fructose Saccharomyces cerevisiae
-
ADP + D-fructose 6-phosphate
-
?
2.7.1.1 ATP + D-glucose Saccharomyces cerevisiae first step in the process of glycolysis ADP + D-glucose 6-phosphate
-
?
2.7.1.1 ATP + D-mannose Saccharomyces cerevisiae
-
ADP + D-mannose 6-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 commercial preparation
-
Saccharomyces cerevisiae
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.1 additional information
-
-
Saccharomyces cerevisiae
2.7.1.1 120
-
commercial preparation Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 ATP + D-fructose
-
Saccharomyces cerevisiae ADP + D-fructose 6-phosphate
-
?
2.7.1.1 ATP + D-glucose
-
Saccharomyces cerevisiae ADP + D-glucose 6-phosphate
-
?
2.7.1.1 ATP + D-glucose first step in the process of glycolysis Saccharomyces cerevisiae ADP + D-glucose 6-phosphate
-
?
2.7.1.1 ATP + D-mannose
-
Saccharomyces cerevisiae ADP + D-mannose 6-phosphate
-
?
2.7.1.1 additional information relatively nonspecific enzyme Saccharomyces cerevisiae ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.1 ATP-D-hexose-6-phosphotransferase
-
Saccharomyces cerevisiae
2.7.1.1 HK
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.1 22
-
assay at room temperature Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.1 1.06
-
D-glucose pH 7.5, 22°C, soluble enzyme Saccharomyces cerevisiae
2.7.1.1 1.67
-
D-glucose pH 7.5, 22°C, immobilized enzyme Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.1 7.5
-
assay at Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP
-
Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.1 0.122
-
ADP pH 7.5, 22°C, versus ATP, dependennt on Mg2+ concentration Saccharomyces cerevisiae