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Literature summary extracted from

  • Vaandrager, A.B.; Hogema, B.M.; de Jonge, H.R.
    Molecular properties and biological functions of cGMP-dependent protein kinase II (2005), Front. Biosci., 10, 2150-2164.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 cGMP cGK I and cGK II contain a high and a low affinity binding site for cGMP with opposite orientation in cGK II compared to cGK I Mammalia
2.7.11.12 additional information isozymes cGK I and cGK II exhibit different affinity for cGMP analogues, overview Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.12 additional information cGK II contains an autoinhibitory region Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.12 membrane isozyme cGK II bound by a myristoyl moiety Mammalia 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.12 additional information Mammalia isozymes cGK I and cGK II are functionally distinct, isozyme cGK II is involved in regulation of electrolyte and water secretion by epithelial tissues in response to luminocrinic hormones guanylin and uroguanylin and in the secretory diarrhea provoked by heat-stable enterotoxins, isozyme cGK II also plays a role in the regulation of endochondral ossification by C-type natriuretic peptide, in renin secretion by the kidney, aldosterone secretion by the adrenal, and adjustment of the biological clock ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Mammalia
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 2 genes encoding isozymes cGK I and cGK II, respectively
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 brain isozyme cGK II Mammalia
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2.7.11.12 intestine isozyme cGK II Mammalia
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2.7.11.12 kidney isozyme cGK II Mammalia
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2.7.11.12 additional information isozymes cGK I and cGK II show different tissue distribution and expression patterns Mammalia
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 additional information isozymes cGK I and cGK II are functionally distinct, isozyme cGK II is involved in regulation of electrolyte and water secretion by epithelial tissues in response to luminocrinic hormones guanylin and uroguanylin and in the secretory diarrhea provoked by heat-stable enterotoxins, isozyme cGK II also plays a role in the regulation of endochondral ossification by C-type natriuretic peptide, in renin secretion by the kidney, aldosterone secretion by the adrenal, and adjustment of the biological clock Mammalia ?
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 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.12 additional information domain structure of cGK II compared to the structure of cGK Ialpha and beta, cGK II is composed of an N-terminal regulatory domain, a dimerization, an autoinhibitory region, two cGMP-binding domains, and a C-terminal catalytic domain Mammalia

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 cGK I
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 Mammalia
2.7.11.12 cGK II
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 Mammalia
2.7.11.12 cGMP-dependent protein kinase I
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 Mammalia
2.7.11.12 cGMP-dependent protein kinase II
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 Mammalia
2.7.11.12 type I cGMP-dependent protein kinase
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 Mammalia
2.7.11.12 Type II cGMP-dependent protein kinase
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 Mammalia